protein coding gene - rho4 (SPAC16A10.04) - Rho family GTPase Rho4

Gene summary

Standard name

rho4

Systematic ID

SPAC16A10.04

Product

Rho family GTPase Rho4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q874R1

ORFeome ID

16/16F09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3087013..3088619 forward strand

Annotation

Protein features

Orthologs

• RHOA (HGNC:667) Homo sapiens
• RHOB (HGNC:668) Homo sapiens
• RHOC (HGNC:669) Homo sapiens
• rho4 (SJAG_01774) Schizosaccharomyces japonicus
• RHO4 (YKR055W) Saccharomyces cerevisiae

References / Literature

PMID:16421249 - Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.

García P et al. Mol Biol Cell 2006 Apr;17(4):1620-31

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23966468 - Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.

Zhu YH et al. Mol Biol Cell 2013 Oct;24(20):3187-204

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:25411334 - The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.

Wang N et al. Mol Biol Cell 2015 Jan 15;26(2):238-55

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:14637153 - Role of guanine nucleotide exchange factors for Rho family GTPases in the regulation of cell morphology and actin cytoskeleton in fission yeast.

Iwaki N et al. Biochem Biophys Res Commun 2003 Dec 12;312(2):414-20

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:12653963 - The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast.

Nakano K et al. Genes Cells 2003 Apr;8(4):357-70

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:25651781 - Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.

Doi A et al. Genes Cells 2015 Apr;20(4):310-23

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:18793338 - Rga2 is a Rho2 GAP that regulates morphogenesis and cell integrity in S. pombe.

Villar-Tajadura MA et al. Mol Microbiol 2008 Nov;70(4):867-81

PMID:12796297 - Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe.

Santos B et al. Eukaryot Cell 2003 Jun;2(3):521-33

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:16415366 - A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.

Jin QW et al. Genetics 2006 Apr;172(4):2101-12

PMID:16215171 - Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.

Santos B et al. Eukaryot Cell 2005 Oct;4(10):1639-45

GO_REF:0000051 - S. pombe keyword mapping

PMID:25724972 - Rho4 interaction with exocyst and septins regulates cell separation in fission yeast.

Pérez P et al. Microbiology (Reading) 2015 May;161(Pt 5):948-959

PMID:31666919 - Rho Family GTPases in Fission Yeast Cytokinesis.

Hercyk B et al. Commun Integr Biol 2019;12(1):171-180

PMID:24947517 - The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.

Muñoz S et al. J Biol Chem 2014 Aug 08;289(32):21995-2007