protein coding gene - taz1 (SPAC16A10.07c) - shelterin complex double-stranded DNA binding subunit Taz1

Gene summary

Standard name

taz1

Systematic ID

SPAC16A10.07c

Product

shelterin complex double-stranded DNA binding subunit Taz1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

myb1, myb, lot3

UniProt ID

P79005

ORFeome ID

27/27C12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3091021..3093260 reverse strand

Annotation

Protein features

Orthologs

• TERF1 (HGNC:11728) Homo sapiens
• TERF2 (HGNC:11729) Homo sapiens
• taz1 (SJAG_01777) Schizosaccharomyces japonicus

References / Literature

PMID:20040595 - Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.

Khair L et al. J Biol Chem 2010 Feb 19;285(8):5327-37

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:11676925 - spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast.

Kanoh J et al. Curr Biol 2001 Oct 16;11(20):1624-30

PMID:27264871 - Taz1-Shelterin Promotes Facultative Heterochromatin Assembly at Chromosome-Internal Sites Containing Late Replication Origins.

Zofall M et al. Mol Cell 2016 Jun 16;62(6):862-874

PMID:37243596 - Stn1-Ten1 and Taz1 independently promote replication of subtelomeric fragile sequences in fission yeast.

Vaurs M et al. Cell Rep 2023 Jun 27;42(6):112537

PMID:12861005 - Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres.

Tomita K et al. Mol Cell Biol 2003 Aug;23(15):5186-97

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11172711 - The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions.

Ferreira MG et al. Mol Cell 2001 Jan;7(1):55-63

PMID:15932060 - The telomere-binding protein Taz1p as a target for modification by a SUMO-1 homologue in fission yeast.

Spink K et al. Biochem Genet 2005 Apr;43(3-4):103-17

PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62

PMID:23084836 - Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation.

Tanaka A et al. Mol Cell 2012 Nov 30;48(4):532-46

PMID:23188080 - The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.

Reis CC et al. EMBO J 2012 Dec 12;31(24):4576-86

PMID:26988418 - The proper connection between shelterin components is required for telomeric heterochromatin assembly.

Wang J et al. Genes Dev 2016 Apr 01;30(7):827-39

PMID:25245948 - Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Wang J et al. Nucleic Acids Res 2014 Oct;42(18):11419-32

PMID:20709788 - Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.

Motwani T et al. Eukaryot Cell 2010 Oct;9(10):1612-21

PMID:10572167 - Taz1p and Teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences.

Vassetzky NS et al. Nucleic Acids Res 1999 Dec 15;27(24):4687-94

PMID:27320927 - Rif1 Regulates the Fate of DNA Entanglements during Mitosis.

Zaaijer S et al. Cell Rep 2016 Jun 28;16(1):148-160

PMID:24240238 - Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Tadeo X et al. Genes Dev 2013 Nov 15;27(22):2489-99

PMID:29422503 - LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK et al. Nat Commun 2018 Feb 08;9(1):586

PMID:31206516 - Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.

Sorida M et al. PLoS Genet 2019 Jun;15(6):e1008129

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:15383525 - Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures.

Tomaska L et al. J Biol Chem 2004 Dec 03;279(49):50764-72

PMID:16199868 - Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing.

Gómez EB et al. Mol Cell Biol 2005 Oct;25(20):8887-903

PMID:9034194 - Regulation of telomere length and function by a Myb-domain protein in fission yeast.

Cooper JP et al. Nature 1997 Feb 20;385(6618):744-7

PMID:9572143 - Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination.

Cooper JP et al. Nature 1998 Apr 23;392(6678):828-31

PMID:9774280 - Two modes of survival of fission yeast without telomerase.

Nakamura TM et al. Science 1998 Oct 16;282(5388):493-6

PMID:26744419 - Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.

Barrales RR et al. Genes Dev 2016 Jan 15;30(2):133-48

PMID:31289327 - Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins.

Hasegawa Y et al. Sci Rep 2019 Jul 09;9(1):9946

PMID:23133674 - Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe.

Fujita I et al. PLoS One 2012;7(11):e49151

PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.

Escandell JM et al. EMBO J 2019 Apr 01;38(7)

PMID:15197176 - The fission yeast heterochromatin protein Rik1 is required for telomere clustering during meiosis.

Tuzon CT et al. J Cell Biol 2004 Jun 21;165(6):759-65

PMID:34158470 - Inhibition of MRN activity by a telomere protein motif.

Khayat F et al. Nat Commun 2021 Jun 22;12(1):3856

PMID:10606652 - Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA.

Spink KG et al. Nucleic Acids Res 2000 Jan 15;28(2):527-33

PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.

Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837

PMID:24244195 - Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.

Chang YT et al. PLoS Genet 2013 Nov;9(11):e1003936

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:27183912 - Translin and Trax differentially regulate telomere-associated transcript homeostasis.

Gomez-Escobar N et al. Oncotarget 2016 Jun 07;7(23):33809-20

PMID:19214192 - Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.

Moser BA et al. EMBO J 2009 Apr 08;28(7):810-20

PMID:18615848 - Role of heterochromatin in suppressing subtelomeric recombination in fission yeast.

Bisht KK et al. Yeast 2008 Aug;25(8):537-48

PMID:29422501 - LARP7 family proteins have conserved function in telomerase assembly.

Collopy LC et al. Nat Commun 2018 Feb 08;9(1):557

PMID:27611693 - A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions.

Katsumata K et al. PLoS Genet 2016 Sep;12(9):e1006304

PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5

PMID:16407326 - Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1.

Hansen KR et al. Nucleic Acids Res 2006;34(1):78-88

PMID:16096639 - Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.

Miller KM et al. EMBO J 2005 Sep 07;24(17):3128-35

PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Garg M et al. EMBO Rep 2014 Aug;15(8):871-7

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:28475613 - SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.

Nie M et al. PLoS Genet 2017 May;13(5):e1006776

PMID:12018857 - Fission yeast Rap1 homolog is a telomere-specific silencing factor and interacts with Taz1p.

Park MJ et al. Mol Cells 2002 Apr 30;13(2):327-33

PMID:22959349 - Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation.

Fujita I et al. Curr Biol 2012 Oct 23;22(20):1932-7

PMID:20074552 - Formation of C-terminally truncated version of the Taz1 protein employs cleavage-box structure in mRNA.

Gunisova S et al. Biochem Biophys Res Commun 2010 Feb 12;392(3):391-6

PMID:25131669 - Telomerase activation after recruitment in fission yeast.

Armstrong CA et al. Curr Biol 2014 Sep 08;24(17):2006-11

PMID:27245259 - Telomerase RNA is more than a DNA template.

Webb CJ et al. RNA Biol 2016 Aug 02;13(8):683-9

PMID:15654021 - Mcp6, a meiosis-specific coiled-coil protein of Schizosaccharomyces pombe, localizes to the spindle pole body and is required for horsetail movement and recombination.

Saito TT et al. J Cell Sci 2005 Jan 15;118(Pt 2):447-59

PMID:17632059 - The telomere bouquet controls the meiotic spindle.

Tomita K et al. Cell 2007 Jul 13;130(1):113-26

PMID:29997179 - Shelterin promotes tethering of late replication origins to telomeres for replication-timing control.

Ogawa S et al. EMBO J 2018 Aug 01;37(15)

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:23936074 - Telomeric repeats facilitate CENP-A(Cnp1) incorporation via telomere binding proteins.

Castillo AG et al. PLoS One 2013;8(7):e69673

PMID:41201383 - Combinatorial Analyses of Pre-mRNA Splicing-Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions.

Takeuchi M et al. Genes Cells 2025 Nov;30(6):e70064

PMID:12944481 - Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.

Ueno M et al. Mol Cell Biol 2003 Sep;23(18):6553-63

PMID:25398909 - Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.

Lorenzi LE et al. EMBO J 2015 Jan 02;34(1):115-29

PMID:11676924 - Telomere binding of the Rap1 protein is required for meiosis in fission yeast.

Chikashige Y et al. Curr Biol 2001 Oct 16;11(20):1618-23

PMID:12620220 - The telomere protein Taz1 is required to prevent and repair genomic DNA breaks.

Miller KM et al. Mol Cell 2003 Feb;11(2):303-13

PMID:11270572 - Schizosaccharomyces pombe taf1+ is required for nitrogen starvation-induced sexual development and for entering the dormant GO state.

Ueno M et al. Curr Genet 2001 Jan;38(6):307-13

PMID:21333630 - Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe.

Sugioka-Sugiyama R et al. Biochem Biophys Res Commun 2011 Mar 18;406(3):444-8

PMID:23335786 - Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.

Almeida H et al. Nucleic Acids Res 2013 Mar 01;41(5):3056-67

PMID:9572142 - Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe.

Nimmo ER et al. Nature 1998 Apr 23;392(6678):825-8

PMID:24013504 - Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.

Jun HI et al. Genes Dev 2013 Sep 01;27(17):1917-31

PMID:26804021 - Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Tashiro S et al. Nat Commun 2016 Jan 25;7:10393

PMID:27101289 - Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins.

Sepsiova R et al. PLoS One 2016;11(4):e0154225

PMID:25533340 - Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1.

Hentges P et al. Cell Rep 2014 Dec 24;9(6):2011-7

PMID:26305931 - Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.

Webb CJ et al. Proc Natl Acad Sci U S A 2015 Sep 08;112(36):11312-7

PMID:26990647 - Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Gadaleta MC et al. PLoS Genet 2016 Mar;12(3):e1005943

PMID:20495382 - SMC complexes and topoisomerase II work together so that sister chromatids can work apart.

Tapia-Alveal C et al. Cell Cycle 2010 Jun 01;9(11):2065-70

PMID:29149597 - Structural Basis for Shelterin Bridge Assembly.

Kim JK et al. Mol Cell 2017 Nov 16;68(4):698-714.e5

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:29774234 - The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Matmati S et al. Sci Adv 2018 May;4(5):eaar2740

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:18160711 - Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.

Subramanian L et al. Mol Cell Biol 2008 Mar;28(5):1443-55

PMID:10855500 - Characterization of fission yeast meiotic mutants based on live observation of meiotic prophase nuclear movement.

Hiraoka Y et al. Chromosoma 2000;109(1-2):103-9

PMID:17289569 - SHREC, an effector complex for heterochromatic transcriptional silencing.

Sugiyama T et al. Cell 2007 Feb 09;128(3):491-504

PMID:21633354 - Condensin association with histone H2A shapes mitotic chromosomes.

Tada K et al. Nature 2011 Jun 01;474(7352):477-83

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:12676088 - Telomere maintenance in fission yeast requires an Est1 ortholog.

Beernink HT et al. Curr Biol 2003 Apr 01;13(7):575-80

PMID:26088418 - Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2.

Deng W et al. Cell Res 2015 Jul;25(7):881-4

PMID:15485922 - Fission yeast Dna2 is required for generation of the telomeric single-strand overhang.

Tomita K et al. Mol Cell Biol 2004 Nov;24(21):9557-67

PMID:34255844 - The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.

Liu J et al. Nucleic Acids Res 2021 Aug 20;49(14):8110-8119

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:31131414 - Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.

Inoue H et al. Nucleic Acids Res 2019 Jul 26;47(13):6871-6884

PMID:22987637 - Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast.

Tazumi A et al. Genes Dev 2012 Sep 15;26(18):2050-62

PMID:17429064 - Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.

Kibe T et al. Mol Biol Cell 2007 Jun;18(6):2378-87

PMID:20661445 - Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.

Rozenzhak S et al. PLoS Genet 2010 Jul 22;6(7):e1001032

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:27889481 - Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.

Fernández-Álvarez A et al. Dev Cell 2016 Dec 05;39(5):544-559

PMID:28404620 - Accumulation of RNA on chromatin disrupts heterochromatic silencing.

Brönner C et al. Genome Res 2017 Jul;27(7):1174-1183

PMID:12196391 - Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

Nakamura TM et al. Genetics 2002 Aug;161(4):1437-52

PMID:26063574 - Minishelterins separate telomere length regulation and end protection in fission yeast.

Pan L et al. Genes Dev 2015 Jun 01;29(11):1164-74

PMID:21217703 - A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.

Chen Y et al. Nat Struct Mol Biol 2011 Feb;18(2):213-21

PMID:22279046 - Rif1 is a global regulator of timing of replication origin firing in fission yeast.

Hayano M et al. Genes Dev 2012 Jan 15;26(2):137-50