protein coding gene - mot2 (SPAC16C9.04c) - CCR4-Not complex ubiquitin-protein ligase E3 subunit 4

Gene summary

Standard name

mot2

Systematic ID

SPAC16C9.04c

Product

CCR4-Not complex ubiquitin-protein ligase E3 subunit 4

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

not4

UniProt ID

Q09818

ORFeome ID

25/25G07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 796876..798802 reverse strand

Annotation

Protein features

Orthologs

• CNOT4 (HGNC:7880) Homo sapiens
• mot2 (SJAG_03883) Schizosaccharomyces japonicus
• MOT2 (YER068W) Saccharomyces cerevisiae

References / Literature

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:28404620 - Accumulation of RNA on chromatin disrupts heterochromatic silencing.

Brönner C et al. Genome Res 2017 Jul;27(7):1174-1183

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:37279920 - A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading.

Challal D et al. Genetics 2023 Aug 09;224(4)

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:40185772 - A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors.

Leroy E et al. Nat Commun 2025 Apr 05;16(1):3250

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:33536434 - A scaffold lncRNA shapes the mitosis to meiosis switch.

Andric V et al. Nat Commun 2021 Feb 03;12(1):770

PMID:30601114 - RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not.

Webster MW et al. Elife 2019 Jan 02;8

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:41184513 - Phosphorylation-dependent tuning of mRNA deadenylation rates.

Stowell JAW et al. Nat Struct Mol Biol 2025 Nov 03;

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:27851962 - Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1.

Stowell JAW et al. Cell Rep 2016 Nov 15;17(8):1978-1989

PMID:26804377 - The architecture of the Schizosaccharomyces pombe CCR4-NOT complex.

Ukleja M et al. Nat Commun 2016 Jan 25;7:10433

PMID:26942678 - Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.

Sugiyama T et al. Mol Cell 2016 Mar 03;61(5):747-759

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

GO_REF:0000002 - Comments

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.

Simonetti F et al. Elife 2017 Aug 25;6

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:29932902 - mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases.

Webster MW et al. Mol Cell 2018 Jun 21;70(6):1089-1100.e8