PomBase home

protein coding gene - vph1 (SPAC16E8.07c) - V-type ATPase V0 subunit a

Gene summary

Standard name
vph1
Systematic ID
SPAC16E8.07c
Product
V-type ATPase V0 subunit a
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13742
ORFeome ID
28/28H06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3510331..3513028 reverse strand

Annotation

Disease association

MONDO:0018163 - autosomal recessive cutis laxa type 2A

References:

MONDO:0009815 - autosomal recessive osteopetrosis 1

References:

MONDO:0015286 - congenital disorder of glycosylation

References:

MONDO:0031021 - developmental and epileptic encephalopathy 104

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0859265 - neurodevelopmental disorder with epilepsy and brain atrophy

References:

MONDO:0011268 - renal tubular acidosis, distal, 3, with or without sensorineural hearing loss

References:

MONDO:0010208 - wrinkly skin syndrome

References:

GO biological process

GO:1902600 - proton transmembrane transport

References:

GO:0007035 - vacuolar acidification

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0000329 - fungal-type vacuole membrane

References:

GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0051117 - ATPase binding

References:

GO:0046961 - proton-transporting ATPase activity, rotational mechanism

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002451 - inviable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF01496V_ATPase_IV-ATPase_116kDa_suPFAM
PTHR11629VACUOLAR PROTON ATPASESV-ATPase_116kDa_suPANTHER
PIRSF001293ATP6V0A1V-type_ATPase_116kDa_su_eukaPIRSF
CoilCoilCOILS

Orthologs

References / Literature

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:31341193 - Ent3 and GGA adaptors facilitate diverse anterograde and retrograde trafficking events to and from the prevacuolar endosome.
Yanguas F et al. Sci Rep 2019 Jul 24;9(1):10747
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PB_REF:0000003 - Disease Association Curation
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
Calvo IA et al. iScience 2021 Nov 19;24(11):103338
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7