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protein coding gene - sua7 (SPAC16E8.16) - transcription factor TFIIB

Gene summary

Standard name
sua7
Systematic ID
SPAC16E8.16
Product
transcription factor TFIIB
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13749
ORFeome ID
18/18D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3530327..3532143 forward strand

Annotation

GO biological process

GO:0051123 - RNA polymerase II preinitiation complex assembly

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO:0001174 - transcriptional start site selection at RNA polymerase II promoter

References:

GO cellular component

GO:0005634 - nucleus

References:

GO:0097550 - transcription preinitiation complex

References:

GO molecular function

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

GO:0017025 - TBP-class protein binding

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0005229 - decreased transcription from RNA polymerase II promoter during vegetative growth

References:

Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF08271Zn_Ribbon_TFZnf_TFIIBPFAM
PF00382TFIIBTFIIB_cyclinPFAM
cd20551CYCLIN_TFIIB_rpt1CDD
cd20552CYCLIN_TFIIB_rpt2CDD
PS00782TFIIBTFIIB_CSPROSITE_PATTERNS
PS51134ZF_TFIIBZnf_TFIIBPROSITE_PROFILES
SM00385cyclin_7Cyclin-like_domSMART
PR00685TIFACTORIIBTFIIBPRINTS
G3DSA:2.20.25.10:FF:000036FUNFAM
G3DSA:1.10.472.10:FF:000019FUNFAM
G3DSA:1.10.472.170:FF:000001FUNFAM
G3DSA:1.10.472.10:FF:000008FUNFAM
SSF57783Zinc beta-ribbonSUPERFAMILY
SSF47954Cyclin-likeCyclin-like_sfSUPERFAMILY
G3DSA:1.10.472.170GENE3D
G3DSA:1.10.472.10GENE3D
PTHR11618TRANSCRIPTION INITIATION FACTOR IIB-RELATEDTFIIBPANTHER

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.
Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28060464 - RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.
Montes M et al. FEBS J 2017 Feb;284(4):615-633
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:15616156 - Tfg3, a subunit of the general transcription factor TFIIF in Schizosaccharomyces pombe, functions under stress conditions.
Kimura M et al. Nucleic Acids Res 2004;32(22):6706-15
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:12359329 - Cloning, expression and functional characterization of Schizosaccharomyces pombe TFIIB.
Tamayo E et al. Biochim Biophys Acta 2002 Sep 27;1577(3):395-400
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.
Li Y et al. Science 1994 Feb 11;263(5148):805-7
PMID:21981922 - A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein.
Lemieux C et al. Mol Cell 2011 Oct 07;44(1):108-19