protein coding gene - nhp2 (SPAC1782.10c) - box H/ACA snoRNP complex subunit Nhp2

Gene summary

Standard name: nhp2
Systematic ID: SPAC1782.10c
Product: box H/ACA snoRNP complex subunit Nhp2
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9P7H0
ORFeome ID: 04/04C04
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 4772002..4773167 reverse strand

Annotation

Disease association

MONDO:0015780 - dyskeratosis congenita

References:

PB_REF:0000003

MONDO:0013519 - dyskeratosis congenita, autosomal recessive 2

References:

PB_REF:0000006

GO biological process

GO:0031118 - rRNA pseudouridine synthesis

References:

PMID:10502409

GO:0031120 - snRNA pseudouridine synthesis

References:

PMID:10502409

GO cellular component

GO:0031429 - box H/ACA snoRNP complex

References:

PMID:10502409

GO:0005730 - nucleolus

References:

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0034513 - box H/ACA snoRNA binding

References:

PMID:10502409

GO:0019843 - rRNA binding

References:

PMID:10502409

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:25720772

MOD:00047 - O-phospho-L-threonine

References:

PMID:32062975

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

nhp2delta

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

nhp2delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01248	Ribosomal_L7Ae	Ribosomal_eL8/eL30/eS12/Gad45	Pfam
PR00881	L7ARS6FAMILY	Ribosomal_eL8/Nhp2	PRINTS
PR00883	NUCLEARHMG	H/ACA_rnp_Nhp2-like	PRINTS
G3DSA:3.30.1330.30:FF:000015			CATH-FunFam
G3DSA:3.30.1330.30		Ribosomal_eL30-like_sf	CATH-Gene3D
SSF55315		Ribosomal_eL30-like_sf	SUPERFAMILY
PTHR23105		eL8/uL1-like	PANTHER

Orthologs

NHP2 (HGNC:14377) Homo sapiens
nhp2 (SJAG_00083) Schizosaccharomyces japonicus
NHP2 (YDL208W) Saccharomyces cerevisiae

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24081329 - Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.: Grenier St-Sauveur V et al. Mol Cell Biol 2013 Dec;33(23):4718-31
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:10502409 - Functional conservation and cell cycle localization of the Nhp2 core component of H + ACA snoRNPs in fission and budding yeasts.: Maiorano D et al. Exp Cell Res 1999 Oct 10;252(1):165-74
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.: Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.: Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PB_REF:0000003 - Disease Association Curation
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.: Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787