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protein coding gene - SPAC1783.01 - methionine synthase reductase

Gene summary

Systematic ID
SPAC1783.01
Product
methionine synthase reductase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9US28
ORFeome ID
45/45G07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2187206..2190744 forward strand

Annotation

Disease association

MONDO:0004737 - homocystinuria

References:

MONDO:0004736 - inborn disorder of amino acid metabolism

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0009354 - methylcobalamin deficiency type cblE

References:

MONDO:0011120 - neural tube defects, folate-sensitive

References:

GO biological process

GO:0071266 - 'de novo' L-methionine biosynthetic process

References:

GO:0050667 - homocysteine metabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0030586 - [methionine synthase] reductase (NADPH) activity

References:

GO:0050660 - flavin adenine dinucleotide binding

References:

GO:0010181 - FMN binding

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0002634 - resistance to cobalt

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00667FAD_binding_1CysJ-like_FAD-bindingPFAM
PF00175NAD_binding_1OxRdtase_FAD/NAD-bdPFAM
PS51384FAD_FRFAD-bd_FR_typePROSITE_PROFILES
PR00371FPNCRFlavoprot_Pyr_Nucl_cyt_RdtasePRINTS
G3DSA:1.20.990.10:FF:000007FUNFAM
G3DSA:3.40.50.80:FF:000027FUNFAM
SSF52343Ferredoxin reductase-like, C-terminal NADP-linked domainFNR_nucleotide-bdSUPERFAMILY
SSF63380Riboflavin synthase domain-likeRiboflavin_synthase-like_b-brlSUPERFAMILY
G3DSA:3.40.50.80FNR_nucleotide-bdGENE3D
G3DSA:2.40.30.10Translation factorsGENE3D
G3DSA:1.20.990.10NADPH_Cyt_P450_Rdtase_alphaGENE3D
PTHR19384NITRIC OXIDE SYNTHASE-RELATEDPANTHER

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.
Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000003 - Disease Association Curation