protein coding gene - pap1 (SPAC1783.07c) - DNA-binding transcription factor, oxidative stress-responsive Pap1/Caf3

Gene summary

Standard name

pap1

Systematic ID

SPAC1783.07c

Product

DNA-binding transcription factor, oxidative stress-responsive Pap1/Caf3

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

caf3

UniProt ID

Q01663

ORFeome ID

40/40F06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2200353..2202989 reverse strand

Annotation

Protein features

Orthologs

• pap1 (SJAG_04036) Schizosaccharomyces japonicus
• YAP1 (YML007W) Saccharomyces cerevisiae

References / Literature

PMID:24316080 - Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle.

Calvo IA et al. Cell Rep 2013 Dec 12;5(5):1413-24

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:14633985 - RNA-binding protein Csx1 mediates global control of gene expression in response to oxidative stress.

Rodríguez-Gabriel MA et al. EMBO J 2003 Dec 01;22(23):6256-66

PMID:15840944 - Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe.

Yoshida J et al. Cell Struct Funct 2005 Feb;29(5-6):125-38

PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhang L et al. PLoS One 2013;8(7):e68738

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:30181366 - Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast.

Liu Q et al. Antimicrob Agents Chemother 2018 Nov;62(11)

PMID:15052323 - Characterization and regulation of the gamma-glutamyl transpeptidase gene from the fission yeast Schizosaccharomyces pombe.

Park HJ et al. Can J Microbiol 2004 Jan;50(1):61-6

PMID:12896976 - Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1.

Castillo EA et al. J Biol Chem 2003 Oct 17;278(42):40565-72

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:22561704 - Regulation of cell cycle and stress responses under nitrosative stress in Schizosaccharomyces pombe.

Majumdar U et al. Free Radic Biol Med 2012 Jun 1;52(11-12):2186-200

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:14503856 - The thioltransferase (glutaredoxin) 1 gene of fission yeast is regulated by Atf1 and Pap1.

Lim CJ et al. Mol Cells 2003 Aug 31;16(1):123-7

PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:15247218 - A cooperative role for Atf1 and Pap1 in the detoxification of the oxidative stress induced by glucose deprivation in Schizosaccharomyces pombe.

Madrid M et al. J Biol Chem 2004 Oct 01;279(40):41594-602

PMID:11907263 - Distinct regulatory proteins control the graded transcriptional response to increasing H(2)O(2) levels in fission yeast Schizosaccharomyces pombe.

Quinn J et al. Mol Biol Cell 2002 Mar;13(3):805-16

PMID:39761853 - Regulation of sod1 mRNA and protein abundance by zinc in fission yeast is dependent on the CCR4-NOT complex.

Weeks AT et al. J Biol Chem 2025 Jan 04;:108156

PMID:15135546 - Stress-dependent regulation of the gene encoding thioredoxin reductase from the fission yeast.

Hong SM et al. FEMS Microbiol Lett 2004 May 15;234(2):379-85

PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.

Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)

PMID:9287302 - Isolation, expression, and regulation of the pgr1(+) gene encoding glutathione reductase absolutely required for the growth of Schizosaccharomyces pombe.

Lee J et al. J Biol Chem 1997 Sep 12;272(37):23042-9

PMID:9585505 - Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.

Toone WM et al. Genes Dev 1998 May 15;12(10):1453-63

PMID:10749922 - Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.

Nguyen AN et al. Mol Biol Cell 2000 Apr;11(4):1169-81

PMID:15164362 - Transcriptional and post-translational regulation of neutral trehalase in Schizosaccharomyces pombe during thermal stress.

Paredes V et al. Yeast 2004 May;21(7):593-603

PMID:24268782 - A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein.

Brown JD et al. Cell Rep 2013 Dec 12;5(5):1425-35

PMID:10455235 - Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant.

Yamada K et al. Yeast 1999 Aug;15(11):1125-32

PMID:24155978 - Possible involvement of nitric oxide and reactive oxygen species in glucose deprivation-induced activation of transcription factor rst2.

Kato T et al. PLoS One 2013;8(10):e78012

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:23525001 - Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1.

Calvo IA et al. J Cell Sci 2013 May 15;126(Pt 10):2279-84

PMID:10954610 - The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.

Kim M et al. Nucleic Acids Res 2000 Sep 01;28(17):3392-402

PMID:11071922 - A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed.

Crane R et al. Mol Biol Cell 2000 Nov;11(11):3993-4003

PMID:18248428 - The pap1(+) gene of fission yeast is transcriptionally regulated by nitrosative and nutritional stress.

Kim HJ et al. FEMS Microbiol Lett 2008 Mar;280(2):176-81

PMID:18235227 - Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.

Ikeda K et al. Cell Cycle 2008 Feb 01;7(3):358-64

PMID:17530441 - Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe.

Kang GY et al. Mol Biol Rep 2008 Sep;35(3):387-95

PMID:18337696 - Nitrogen depletion causes up-regulation of glutathione content and gamma-glutamyltranspeptidase in Schizosaccharomyces pombe.

Song SH et al. J Microbiol 2008 Feb;46(1):70-4

PMID:25602522 - The impact of the HIRA histone chaperone upon global nucleosome architecture.

Gal C et al. Cell Cycle 2015;14(1):123-34

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:19940942 - Expression of the atf1+ gene is upregulated in fission yeast under nitrosative and nutritional stresses.

Song SH et al. Can J Microbiol 2009 Nov;55(11):1323-7

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:22245228 - Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.

Day AM et al. Mol Cell 2012 Feb 10;45(3):398-408

PMID:10348908 - A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response.

Ohmiya R et al. J Biochem 1999 Jun;125(6):1061-6

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:30181192 - Protection from Disulfide Stress by Inhibition of Pap1 Nuclear Export in Schizosaccharomyces pombe .

Chen Y et al. Genetics 2018 Nov;210(3):857-868

PMID:12442905 - Regulation of the manganese-containing superoxide dismutase gene from fission yeast.

Jung HI et al. Mol Cells 2002 Oct 31;14(2):300-4

PMID:31514053 - Identification of ubiquitin-proteasome system components affecting the degradation of the transcription factor Pap1.

Marte L et al. Redox Biol 2020 Jan;28:101305

PMID:21410566 - Fission yeast Ubr1 ubiquitin ligase influences the oxidative stress response via degradation of active Pap1 bZIP transcription factor in the nucleus.

Kitamura K et al. Mol Microbiol 2011 May;80(3):739-55

PMID:12018855 - Pap1-mediated regulation of thioredoxin gene from Schizosaccharomyces pombe.

Cho YW et al. Mol Cells 2002 Apr 30;13(2):315-21

PMID:15865206 - Carbon source-dependent regulation of a second gene encoding glutaredoxin from the fission yeast Schizosaccharomyces pombe.

Kim HG et al. Mol Biol Rep 2005 Mar;32(1):15-24

PMID:23115244 - Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

Gabrielli N et al. J Biol Chem 2012 Dec 14;287(51):43042-51

PMID:26567340 - Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS.

García P et al. J Biol Chem 2016 Jan 08;291(2):790-9

PMID:24563858 - Thiol-based H2O2 signalling in microbial systems.

Boronat S et al. Redox Biol 2014;2:395-9

PMID:9532803 - Multidrug resistance phenotype conferred by overexpressing bfr2+/pad1+/sks1+ or pap1+ genes and mediated by bfr1+ gene product, a structural and functional homologue of P-glycoprotein in Schizosaccharomyces pombe.

Arioka M et al. Biosci Biotechnol Biochem 1998 Feb;62(2):390-2

PMID:12359231 - Regulation and the role of Cu,Zn-containing superoxide dismutase in cell cycle progression of Schizosaccharomyces pombe.

Lee J et al. Biochem Biophys Res Commun 2002 Oct 04;297(4):854-62

PMID:11350071 - Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe.

Jeong JH et al. Biochem Biophys Res Commun 2001 May 18;283(4):908-14

PMID:20563653 - Protective roles and Pap1-dependent regulation of the Schizosaccharomyces pombe spy1 gene under nitrosative and nutritional stresses.

Kang MH et al. Mol Biol Rep 2011 Feb;38(2):1129-36

PMID:10428959 - Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

Wilkinson MG et al. EMBO J 1999 Aug 02;18(15):4210-21

PMID:24118096 - Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.

García-Santamarina S et al. Mol Microbiol 2013 Dec;90(5):1113-24

PMID:12521310 - The Pap1-independent induction by metal ions of a third gene encoding glutathione S-transferase gene from the fission yeast.

Sa JH et al. Mol Cells 2002 Dec 31;14(3):444-8

PMID:16258244 - Characterization and regulation of the gene encoding monothiol glutaredoxin 3 in the fission yeast Schizosaccharomyces pombe.

Moon JS et al. Mol Cells 2005 Aug 31;20(1):74-82

PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333

PMID:1448080 - Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1.

Toda T et al. Mol Cell Biol 1992 Dec;12(12):5474-84

PMID:12521308 - Pap1-dependent regulation of the GSTII gene from the fission yeast.

Lim CJ et al. Mol Cells 2002 Dec 31;14(3):431-6

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:15358115 - Differential expression and role of two dithiol glutaredoxins Grx1 and Grx2 in Schizosaccharomyces pombe.

Chung WH et al. Biochem Biophys Res Commun 2004 Sep 03;321(4):922-9

PMID:18758731 - The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.

Song JY et al. J Microbiol 2008 Aug;46(4):408-14

PMID:15529002 - Transcriptional regulation of glutathione synthetase in the fission yeast Schizosaccharomyces pombe.

Kim SJ et al. Mol Cells 2004 Oct 31;18(2):242-8

PMID:8569688 - Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+.

Kumada K et al. Mol Gen Genet 1996 Jan 15;250(1):59-68

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:11017199 - Structural basis for the diversity of DNA recognition by bZIP transcription factors.

Fujii Y et al. Nat Struct Biol 2000 Oct;7(10):889-93

PMID:18003976 - Multiple pathways differentially regulate global oxidative stress responses in fission yeast.

Chen D et al. Mol Biol Cell 2008 Jan;19(1):308-17

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:7929079 - Brefeldin A sensitivity and resistance in Schizosaccharomyces pombe. Isolation of multiple genes conferring resistance.

Turi TG et al. J Biol Chem 1994 Sep 30;269(39):24229-36

PMID:12243351 - Regulation of Schizosaccharomyces pombe gene encoding copper/zinc superoxide dismutase.

Lee YY et al. Mol Cells 2002 Aug 31;14(1):43-9

PMID:16428309 - Effects of four oxidants, menadione, 1-chloro-2,4-dinitrobenzene, hydrogen peroxide and cumene hydroperoxide, on fission yeast Schizosaccharmoyces pombe.

Mutoh N et al. J Biochem 2005 Dec;138(6):797-804

PMID:22279963 - Pap1p-dependent upregulation of thioredoxin 3 and thioredoxin reductase genes from the fission yeast under nitrosative stress.

Park MS et al. Can J Microbiol 2012 Feb;58(2):206-11

PMID:38499131 - The deletion of ppr2 interferes iron sensing and leads to oxidative stress response in Schizosaccharomyces pombe.

Liu Z et al. Mitochondrion 2024 Mar 16;:101875

PMID:17016471 - Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.

Tafforeau L et al. EMBO J 2006 Oct 04;25(19):4547-56

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842

PMID:11129048 - The Prr1 response regulator is essential for transcription of ste11+ and for sexual development in fission yeast.

Ohmiya R et al. Mol Gen Genet 2000 Nov;264(4):441-51

PMID:12073089 - Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.

Mutoh N et al. Curr Genet 2002 May;41(2):82-8

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:12100563 - Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues.

Castillo EA et al. Mol Microbiol 2002 Jul;45(1):243-54

PMID:12063243 - Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe.

Veal EA et al. J Biol Chem 2002 Sep 20;277(38):35523-31

PMID:11453251 - Factors involved in the regulation of the Schizosaccharomyces pombe malic enzyme gene.

Groenewald M et al. Curr Genet 2001 Jun;39(4):222-30

PMID:30426027 - Pap1 + confers microtubule damage resistance to mut2a , an extragenic suppressor of the rad26:4A allele in S. pombe .

Paliwal S et al. Mol Biol Res Commun 2018 Sep;7(3):97-106

PMID:17473896 - Stress-dependent regulation of Pbh1, a BIR domain-containing protein, in the fission yeast.

Cho NC et al. Can J Microbiol 2006 Dec;52(12):1261-5

PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.

Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009

PMID:16087744 - Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe.

Rodríguez-Gabriel MA et al. Eukaryot Cell 2005 Aug;4(8):1396-402

PMID:28528978 - Multimodal control of transcription factor Pap1 in Schizosaccharomyces pombe under nitrosative stress.

Kar P et al. Biochem Biophys Res Commun 2017 Jul 15;489(1):42-47

PMID:16278451 - Activation of AP-1-dependent transcription by a truncated translation initiation factor.

Jenkins CC et al. Eukaryot Cell 2005 Nov;4(11):1840-50

PMID:1899230 - Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

Toda T et al. Genes Dev 1991 Jan;5(1):60-73

PMID:17725619 - Protective role and regulation of Rad9 from the fission yeast Schizosaccharomyces pombe.

Kang MH et al. FEMS Microbiol Lett 2007 Oct;275(2):270-7

PMID:24587136 - The oxidative stress responsive transcription factor Pap1 confers DNA damage resistance on checkpoint-deficient fission yeast cells.

Belfield C et al. PLoS One 2014;9(2):e89936

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:7769002 - A novel essential fission yeast gene pad1+ positively regulates pap1(+)-dependent transcription and is implicated in the maintenance of chromosome structure.

Shimanuki M et al. J Cell Sci 1995 Feb;108 ( Pt 2):569-79

PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.

Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115

PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.

Vachon L et al. Genetics 2013 Aug;194(4):873-84

PMID:22344694 - The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.

Calvo IA et al. Nucleic Acids Res 2012 Jun;40(11):4816-24

PMID:15165244 - Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration.

Vivancos AP et al. Mol Microbiol 2004 Jun;52(5):1427-35

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:24696293 - Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.

Shimasaki T et al. Mol Genet Genomics 2014 Aug;289(4):685-93

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:15937127 - The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression.

Umeda M et al. Genetics 2005 Sep;171(1):7-21

PMID:16141205 - The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe.

Zuin A et al. J Biol Chem 2005 Nov 04;280(44):36708-13

PMID:23209828 - Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the Pap1 transcription factor.

Penney M et al. PLoS One 2012;7(11):e50796

PMID:14758541 - The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe.

Benko Z et al. Mol Genet Genomics 2004 Mar;271(2):161-70

PMID:17205051 - Carbon source-dependent regulation of the Schizosaccharomyces pombe pbh1 gene.

Kim SJ et al. J Microbiol 2006 Dec;44(6):689-93

PMID:12787490 - Regulation of the gene encoding glutathione synthetase from the fission yeast.

Kim SJ et al. J Biochem Mol Biol 2003 May 31;36(3):326-31

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:12855726 - Different roles for the stress-activated protein kinase pathway in the regulation of trehalose metabolism in Schizosaccharomyces pombe.

Paredes V et al. Microbiology (Reading) 2003 Jul;149(Pt 7):1745-1752

PMID:15650330 - Differential regulation of three genes encoding glutathione S-transferases in Schizosaccharomyces pombe.

Kim HG et al. Mol Cells 2004 Dec 31;18(3):332-9

PMID:10329722 - A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1.

Kudo N et al. J Biol Chem 1999 May 21;274(21):15151-8

PMID:16458193 - Effect of nitrosative stress on Schizosaccharomyces pombe: inactivation of glutathione reductase by peroxynitrite.

Sahoo R et al. Free Radic Biol Med 2006 Feb 15;40(4):625-31

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:10731689 - Role of Atf1 and Pap1 in the induction of the catalase gene of fission yeast schizosaccharomyces pombe.

Nakagawa CW et al. J Biochem 2000 Feb;127(2):233-8

PMID:15650694 - Transcriptional regulation of the Schizosaccharomyces pombe gene encoding glutathione S-transferase I by a transcription factor Pap1.

Kim HG et al. J Microbiol 2004 Dec;42(4):353-6

PMID:11318103 - Sequence of Crm1/exportin 1 mutant alleles reveals critical sites associated with multidrug resistance.

Carobbio S et al. Curr Genet 2001 Feb;39(1):2-9

PMID:16258240 - The fission yeast gene encoding monothiol glutaredoxin 5 is regulated by nitrosative and osmotic stresses.

Kim HG et al. Mol Cells 2005 Aug 31;20(1):43-50

PMID:27664222 - A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe.

He Y et al. Nucleic Acids Res 2017 Jan 09;45(1):106-114

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15765057 - The Schizosaccharomyces pombe gene encoding gamma-glutamyl transpeptidase I is regulated by non-fermentable carbon sources and nitrogen starvation.

Kim HG et al. J Microbiol 2005 Feb;43(1):44-8

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:33225241 - The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1.

Boronat S et al. iScience 2020 Nov 20;23(11):101725

PMID:9211790 - Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle.

Benko Z et al. Curr Genet 1997 Jun;31(6):481-7

PMID:16175211 - Stress-dependent regulation of a monothiol glutaredoxin gene from Schizosaccharomyces pombe.

Kim HG et al. Can J Microbiol 2005 Jul;51(7):613-20

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:32908306 - Epigenetic gene silencing by heterochromatin primes fungal resistance.

Torres-Garcia S et al. Nature 2020 Sep;585(7825):453-458

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:9757124 - Crystallographic characterization of Pap1-DNA complex.

Fujii Y et al. Acta Crystallogr D Biol Crystallogr 1998 Sep 01;54(Pt 5):1014-6

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:28652406 - Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

Salat-Canela C et al. J Biol Chem 2017 Aug 18;292(33):13635-13644

PMID:7646493 - Characterization of a novel Schizosaccharomyces pombe multidrug resistance transporter conferring brefeldin A resistance.

Turi TG et al. Biochem Biophys Res Commun 1995 Aug 15;213(2):410-8

PMID:24521463 - A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

Paulo E et al. Mol Microbiol 2014 Apr;92(2):246-57

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