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protein coding gene - cut11 (SPAC1786.03) - spindle pole body docking protein Cut11

Gene summary

Standard name
cut11
Systematic ID
SPAC1786.03
Product
spindle pole body docking protein Cut11
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC24C9.01
UniProt ID
O13961
ORFeome ID
36/36H02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3037686..3039659 forward strand

Annotation

Disease association

MONDO:0979875 - neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima

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GO biological process

GO:1903087 - mitotic spindle pole body duplication

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GO:0140480 - mitotic spindle pole body insertion into the nuclear envelope

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GO:1990608 - mitotic spindle pole body localization

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GO:0006999 - nuclear pore organization

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GO cellular component

GO:0140512 - mitotic nuclear bridge midzone

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GO:0140599 - mitotic nuclear bridge midzone membrane domain

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GO:0044732 - mitotic spindle pole body

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GO:0005635 - nuclear envelope

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GO:0005643 - nuclear pore

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GO:0070762 - nuclear pore transmembrane ring

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GO molecular function

GO:0106166 - spindle pole body-nuclear membrane anchor activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00048 - O4'-phospho-L-tyrosine

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Multi-locus phenotype

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

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Genotypes:

FYPO:0003567 - abnormal mitotic spindle pole body insertion into nuclear envelope

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Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

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Genotypes:

FYPO:0000229 - cut

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Genotypes:

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0004648 - delayed onset of mitotic spindle assembly

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Genotypes:

FYPO:0000316 - inviable after spore germination

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0002018 - mitotic spindle absent from cell

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0007859 - nuclear division in absence of mitotic spindle

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000338 - abnormal mitotic spindle

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Genotypes:

FYPO:0003568 - abnormal mitotic spindle pole body insertion into nuclear envelope, with spindle pole body in nucleoplasm

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Genotypes:

FYPO:0000939 - abnormal protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0001946 - abolished mitotic sister chromatid separation

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Genotypes:

FYPO:0001792 - abolished mitotic spindle pole body duplication

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Genotypes:

FYPO:0007426 - abolished new mitotic spindle pole body insertion into nuclear envelope

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Genotypes:

FYPO:0001978 - bent mitotic spindle

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Genotypes:

FYPO:0000229 - cut

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Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

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Genotypes:

FYPO:0002822 - decreased protein localization to mitotic spindle pole body during mitosis

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Genotypes:

FYPO:0001514 - decreased protein localization to nucleus during vegetative growth

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Genotypes:

FYPO:0007428 - delayed onset of mitotic spindle microtubule nucleation from old spindle pole body

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Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001387 - loss of viability at high temperature

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Genotypes:

FYPO:0000276 - monopolar mitotic spindle

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Genotypes:

FYPO:0006592 - monopolar mitotic spindle nucleated from old spindle pole body

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Genotypes:

FYPO:0003788 - nuclear envelope protrusion present during mitosis

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Genotypes:

FYPO:0000772 - perforated nuclear envelope

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Genotypes:

FYPO:0000732 - short bipolar mitotic spindle

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Genotypes:

FYPO:0006801 - spindle pole bodies present in increased numbers during vegetative growth

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF09531Ndc1_NupNucleoporin_prot_Ndc1/NupPfam
PTHR13269Nucleoporin_prot_Ndc1/NupPANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:41526646 - Development of a global screening system for detecting protein-protein interactions by luminescence complementation in fission yeast.
Azadeh F et al. Sci Rep 2026 Jan 12;
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:11694582 - pkl1(+)and klp2(+): Two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis.
Troxell CL et al. Mol Biol Cell 2001 Nov;12(11):3476-88
PMID:24963130 - The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body.
Wälde S et al. J Cell Sci 2014 Aug 15;127(Pt 16):3625-40
PMID:19487457 - The S. pombe mitotic regulator Cut12 promotes spindle pole body activation and integration into the nuclear envelope.
Tallada VA et al. J Cell Biol 2009 Jun 01;185(5):875-88
PMID:30427751 - The J-domain cochaperone Rsp1 interacts with Mto1 to organize noncentrosomal microtubule assembly.
Shen J et al. Mol Biol Cell 2019 Jan 15;30(2):256-267
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:22042620 - Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.
Tamm T et al. J Cell Biol 2011 Oct 31;195(3):467-84
PMID:23576550 - The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2.
Mori R et al. Mol Biol Cell 2013 Jun;24(11):1713-24, S1-8
PMID:37792890 - Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.
Willet AH et al. PLoS Genet 2023 Oct;19(10):e1010987
PMID:38917328 - SUMO protease and proteasome recruitment at the nuclear periphery differently affect replication dynamics at arrested forks.
Schirmeisen K et al. Nucleic Acids Res 2024 Jun 25;
PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.
Hirano T et al. EMBO J 1986 Nov;5(11):2973-9
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:34133218 - Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
Bestul AJ et al. Mol Biol Cell 2021 Aug 01;32(16):1487-1500
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.
Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477
PMID:24637836 - Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.
Asakawa H et al. Nucleus 2014;5(2):149-62
PMID:22895252 - A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA.
Kawakami K et al. Genes Dev 2012 Aug 15;26(16):1811-24
PMID:11927555 - The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.
Krien MJ et al. EMBO J 2002 Apr 02;21(7):1713-22
PMID:11086011 - The fission yeast ran GTPase is required for microtubule integrity.
Fleig U et al. J Cell Biol 2000 Nov 27;151(5):1101-11
PMID:19942852 - Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation.
Fong CS et al. EMBO J 2010 Jan 06;29(1):120-30
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:25103238 - Tts1, the fission yeast homologue of the TMEM33 family, functions in NE remodeling during mitosis.
Zhang D et al. Mol Biol Cell 2014 Oct 01;25(19):2970-83
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.
Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.
Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
PMID:9763447 - cut11(+): A gene required for cell cycle-dependent spindle pole body anchoring in the nuclear envelope and bipolar spindle formation in Schizosaccharomyces pombe.
West RR et al. Mol Biol Cell 1998 Oct;9(10):2839-55
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:20967237 - Fission yeast cells undergo nuclear division in the absence of spindle microtubules.
Castagnetti S et al. PLoS Biol 2010 Oct 12;8(10):e1000512
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27889481 - Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.
Fernández-Álvarez A et al. Dev Cell 2016 Dec 05;39(5):544-559
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22174761 - Roles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.
Wu P et al. PLoS One 2011;6(12):e28000
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20434336 - The cortical ER network limits the permissive zone for actomyosin ring assembly.
Zhang D et al. Curr Biol 2010 Jun 08;20(11):1029-34
PMID:32502403 - Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast.
Expósito-Serrano M et al. Curr Biol 2020 Aug 17;30(16):3212-3222.e2
PMID:32848252 - Closed mitosis requires local disassembly of the nuclear envelope.
Dey G et al. Nature 2020 Sep;585(7823):119-123