protein coding gene - vma6 (SPAC17A2.03c) - V-type ATPase V0 subunit d

Gene summary

Standard name: vma6
Systematic ID: SPAC17A2.03c
Product: V-type ATPase V0 subunit d
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O13753
ORFeome ID: 43/43G04
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 3554534..3556545 reverse strand

Annotation

GO biological process

GO:1902600 - proton transmembrane transport

References:

GO_REF:0000111

GO:0007035 - vacuolar acidification

References:

GO_REF:0000033

GO:0007034 - vacuolar transport

References:

GO_REF:0000033

GO cellular component

GO:0000329 - fungal-type vacuole membrane

References:

GO_REF:0000033

GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain

References:

GO_REF:0000024

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO_REF:0000111

GO:0046961 - proton-transporting ATPase activity, rotational mechanism

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

PMID:23697806

Genotypes:

vma6delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

vma6delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01992	vATP-synt_AC39	ATPase_V0-cplx_csu/dsu	PFAM
G3DSA:1.20.1690.10:FF:000001			FUNFAM
G3DSA:1.20.1690.10:FF:000003			FUNFAM
SSF103486	V-type ATP synthase subunit C	ATPase_csu/dsu_sf	SUPERFAMILY
G3DSA:1.20.1690.10		V-type_ATPase_csu/dsu	GENE3D
G3DSA:1.10.132.50	ATP synthase (C/AC39) subunit, domain 3	V-type_ATPase_csu/dsu_dom_3	GENE3D
PTHR11028	VACUOLAR ATP SYNTHASE SUBUNIT AC39	ATPase_V0-cplx_dsu	PANTHER
PIRSF018497	V-ATP_synth_D	ATPase_V0-cplx_dsu	PIRSF

Orthologs

ATP6V0D1 (HGNC:13724) Homo sapiens
ATP6V0D2 (HGNC:18266) Homo sapiens
vma6 (SJAG_01913) Schizosaccharomyces japonicus
VMA6 (YLR447C) Saccharomyces cerevisiae

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.