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protein coding gene - rrp1 (SPAC17A2.12) - ATP-dependent chromatin remodeler/ ubiquitin-protein ligase E3

Gene summary

Standard name
rrp1
Systematic ID
SPAC17A2.12
Product
ATP-dependent chromatin remodeler/ ubiquitin-protein ligase E3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13762
ORFeome ID
38/38H11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3580223..3583005 forward strand

Annotation

GO biological process

GO:0000724 - double-strand break repair via homologous recombination

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GO cellular component

GO:0000785 - chromatin

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GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0035861 - site of double-strand break

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GO molecular function

GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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GO:0061995 - ATP-dependent protein-DNA complex displacement activity

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GO:0003690 - double-stranded DNA binding

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GO:0003697 - single-stranded DNA binding

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GO:0061630 - ubiquitin protein ligase activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Protein features

PBO:0111747 - DEAD/DEAH box helicase

PBO:0111748 - helicase C-terminal domain

PBO:0111749 - ubiquitin-protein ligase E3

PBO:0111746 - zf-C3HC4 type (RING finger)

PBO:0111743 - zinc finger protein

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009078 - decreased cell population growth on ethanol carbon source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0000220 - increased centromeric outer repeat transcript level

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

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Genotypes:

FYPO:0001689 - normal growth on 4-nitroquinoline N-oxide

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Genotypes:

FYPO:0001690 - normal growth on camptothecin

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Genotypes:

FYPO:0006150 - normal growth on etoposide

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0001124 - normal vegetative cell size

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Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0009084 - sensitive to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00271Helicase_CHelicase_C-likePFAM
PF00176SNF2-rel_domSNF2_NPFAM
cd18008DEXDc_SHPRH-likeCDD
cd18793SF2_C_SNFSNF2/RAD54-like_CCDD
PS51192HELICASE_ATP_BIND_1Helicase_ATP-bdPROSITE_PROFILES
PS51194HELICASE_CTERHelicase_C-likePROSITE_PROFILES
PS50089ZF_RING_2Znf_RINGPROSITE_PROFILES
SM00490helicmild6Helicase_C-likeSMART
SM00487ultradead3Helicase_ATP-bdSMART
SM00184ring_2Znf_RINGSMART
G3DSA:3.40.50.300:FF:002704FUNFAM
G3DSA:3.30.40.10:FF:001271FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
SSF57850RING/U-boxSUPERFAMILY
G3DSA:3.40.50.10810SNF2-like_sfGENE3D
G3DSA:3.30.40.10Zinc/RING finger domain, C3HC4 (zinc finger)Znf_RING/FYVE/PHDGENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR45626TRANSCRIPTION TERMINATION FACTOR 2-RELATEDPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity

Orthologs

References / Literature

PMID:28552615 - SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
Wei Y et al. Mol Cell 2017 Jun 01;66(5):581-596.e6
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23828040 - Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.
Dziadkowiec D et al. Nucleic Acids Res 2013 Sep;41(17):8196-209
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34157114 - Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast.
Muraszko J et al. Nucleic Acids Res 2021 Jul 09;49(12):6832-6848
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:16931764 - Argonaute slicing is required for heterochromatic silencing and spreading.
Irvine DV et al. Science 2006 Aug 25;313(5790):1134-7
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000002 - Comments
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19185548 - The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.
Dziadkowiec D et al. DNA Repair (Amst) 2009 May 01;8(5):627-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)