protein coding gene - exo2 (SPAC17A5.14) - exonuclease II Exo2

Gene summary

Standard name

exo2

Systematic ID

SPAC17A5.14

Product

exonuclease II Exo2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P40383

ORFeome ID

30/30F03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1778490..1782740 forward strand

Annotation

Protein features

Orthologs

• XRN1 (HGNC:30654) Homo sapiens
• exo2 (SJAG_03276) Schizosaccharomyces japonicus
• XRN1 (YGL173C) Saccharomyces cerevisiae

References / Literature

PMID:27354705 - The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface.

Wurm JP et al. RNA 2016 Sep;22(9):1360-72

PMID:23503588 - The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.

Malecki M et al. EMBO J 2013 Jul 03;32(13):1842-54

PMID:30116786 - Genetic regulation of mitotic competence in G 0 quiescent cells.

Sajiki K et al. Sci Adv 2018 Aug;4(8):eaat5685

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:29114019 - Native elongating transcript sequencing reveals global anti-correlation between sense and antisense nascent transcription in fission yeast.

Wery M et al. RNA 2018 Feb;24(2):196-208

PMID:30967422 - Negative Regulation of the Mis17-Mis6 Centromere Complex by mRNA Decay Pathway and EKC/KEOPS Complex in Schizosaccharomyces pombe .

Xu X et al. G3 (Bethesda) 2019 Jun 05;9(6):1815-1823

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24818994 - The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Jongjitwimol J et al. PLoS One 2014;9(5):e94182

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Ma Y et al. PLoS One 2011;6(8):e23422

PMID:32496538 - Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription.

Sansó M et al. Nucleic Acids Res 2020 Jul 27;48(13):7154-7168

PMID:28404620 - Accumulation of RNA on chromatin disrupts heterochromatic silencing.

Brönner C et al. Genome Res 2017 Jul;27(7):1174-1183

PMID:24755092 - Cotranslational protein-RNA associations predict protein-protein interactions.

Duncan CD et al. BMC Genomics 2014 Apr 22;15:298

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:39358553 - Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells.

Anver S et al. EMBO Rep 2024 Oct 02;

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Zhang K et al. Science 2011 Mar 25;331(6024):1624-7

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .

Guydosh NR et al. Elife 2017 Sep 25;6

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

PMID:29914874 - Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast.

Atkinson SR et al. RNA 2018 Sep;24(9):1195-1213

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:26890608 - A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Gaspa L et al. Cell Cycle 2016;15(5):720-9

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:29975684 - Bases of antisense lncRNA-associated regulation of gene expression in fission yeast.

Wery M et al. PLoS Genet 2018 Jul;14(7):e1007465

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:41298081 - Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.

Araoyinbo A et al. Genes Dev 2025 Nov 26;

PMID:8188690 - A multifunctional exonuclease from vegetative Schizosaccharomyces pombe cells exhibiting in vitro strand exchange activity.

Käslin E et al. J Biol Chem 1994 May 13;269(19):14094-102

PMID:39333464 - Uridylation regulates mRNA decay directionality in fission yeast.

Grochowski M et al. Nat Commun 2024 Sep 27;15(1):8359

PMID:1637812 - A single-stranded DNA exonuclease from Schizosaccharomyces pombe.

Szankasi P et al. Biochemistry 1992 Jul 28;31(29):6769-73

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:8781170 - Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability.

Szankasi P et al. Curr Genet 1996 Sep;30(4):284-93

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:19336419 - Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.

Lemieux C et al. Nucleic Acids Res 2009 Jun;37(10):3418-30

PMID:28031482 - Involvement of fission yeast Pdc2 in RNA degradation and P-body function.

Wang CY et al. RNA 2017 Apr;23(4):493-503

PMID:23319050 - Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.

Wang CY et al. Mol Cell Biol 2013 Mar;33(6):1244-53

PMID:32071154 - Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies.

Hsiao WY et al. Mol Cell Biol 2020 Apr 13;40(9)

PMID:38295128 - A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay.

De Zoysa T et al. PLoS Genet 2024 Jan 31;20(1):e1011146

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87