PomBase home

protein coding gene - rec25 (SPAC17A5.18c) - meiotic recombination protein Rec25

Gene summary

Standard name
rec25
Systematic ID
SPAC17A5.18c
Product
meiotic recombination protein Rec25
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug19
UniProt ID
Q9C115
ORFeome ID
51/51H10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1751076..1753685 reverse strand

Annotation

GO biological process

GO:0010780 - meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

References:

GO:0007131 - reciprocal meiotic recombination

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005829 - cytosol

References:

GO:0030998 - linear element

References:

GO:0005634 - nucleus

References:

Multi-locus phenotype

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000021 - protein present

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004585 - abnormal linear element morphology

References:

Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0000909 - abnormal protein localization to linear element

References:

Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0003181 - abolished meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0006161 - abolished protein localization to chromatin during meiosis I

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0004058 - decreased meiotic recombination at CRE promoter

References:

Genotypes:

FYPO:0005433 - decreased meiotic recombination at hotspot

References:

Genotypes:

FYPO:0003540 - decreased regional homologous chromosome pairing

References:

Genotypes:

FYPO:0005432 - globally decreased mitotic recombination

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

References:

Genotypes:

FYPO:0004665 - linear elements absent from cell

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0000478 - normal meiosis

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0006162 - normal protein localization to chromatin during meiosis I

References:

Genotypes:

FYPO:0003538 - premature meiosis I

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Protein features

IDNameInterPro nameDB name
CoilCOILS

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:27806301 - Meiotic Nuclear Oscillations Are Necessary to Avoid Excessive Chromosome Associations.
Chacón MR et al. Cell Rep 2016 Nov 01;17(6):1632-1645
PMID:28765164 - Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.
Touat-Todeschini L et al. EMBO J 2017 Sep 01;36(17):2626-2641
PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .
Guydosh NR et al. Elife 2017 Sep 25;6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22362333 - Mug20, a novel protein associated with linear elements in fission yeast meiosis.
Estreicher A et al. Curr Genet 2012 Apr;58(2):119-27
PMID:33526714 - Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex in fission yeast.
Wintrebert M et al. J Cell Sci 2021 Feb 22;134(4)
PMID:30217891 - Physical basis for long-distance communication along meiotic chromosomes.
Fowler KR et al. Proc Natl Acad Sci U S A 2018 Oct 02;115(40):E9333-E9342
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62
PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.
Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.
Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30
PMID:23395004 - Protein determinants of meiotic DNA break hot spots.
Fowler KR et al. Mol Cell 2013 Mar 07;49(5):983-96
PMID:33825974 - Linear elements are stable structures along the chromosome axis in fission yeast meiosis.
Ding DQ et al. Chromosoma 2021 Sep;130(2-3):149-162
PMID:19756689 - SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.
Spirek M et al. Chromosoma 2010 Feb;119(1):59-72
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:18514516 - Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination.
Davis L et al. Curr Biol 2008 Jun 03;18(11):849-54
PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.
Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:28469148 - Functional organization of protein determinants of meiotic DNA break hotspots.
Ma L et al. Sci Rep 2017 May 03;7(1):1393
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684