protein coding gene - sam50 (SPAC17C9.06) - SAM complex subunit Sam50

Gene summary

Standard name: sam50
Systematic ID: SPAC17C9.06
Product: SAM complex subunit Sam50
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q10478
ORFeome ID: 24/24D12
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 4488524..4490395 reverse strand

Annotation

GO biological process

GO:0045040 - protein insertion into mitochondrial outer membrane

References:

GO_REF:0000033

GO cellular component

GO:0005739 - mitochondrion

References:

PMID:16823372

GO:0001401 - SAM complex

References:

GO_REF:0000033

GO molecular function

GO:0032977 - membrane insertase activity

References:

GO_REF:0000024

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

MOD:00048 - O4'-phospho-L-tyrosine

References:

PMID:30726745

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

PMID:29432178

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

sam50delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01103	Omp85	Bac_surfAg_D15	PFAM
PS51779	POTRA	POTRA	PROSITE_PROFILES
G3DSA:2.40.160.50	membrane protein fhac: a member of the omp85/tpsb transporter family		GENE3D
G3DSA:3.10.20.310	membrane protein fhac		GENE3D
PTHR12815	SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER	D15-like	PANTHER

Orthologs

SAMM50 (HGNC:24276) Homo sapiens
sam50 (SJAG_01951) Schizosaccharomyces japonicus
SAM50 (YNL026W) Saccharomyces cerevisiae

References / Literature

PMID:21445296 - Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.: Shiroiwa Y et al. PLoS One 2011 Mar 21;6(3):e17761
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.: Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.: Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.: Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:38692277 - A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture.: Kumar A et al. Curr Biol 2024 Apr 24;