protein coding gene - cut8 (SPAC17C9.13c) - tethering factor for nuclear proteasome Cut8

Gene summary

Standard name

cut8

Systematic ID

SPAC17C9.13c

Product

tethering factor for nuclear proteasome Cut8

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P38937

ORFeome ID

09/09H07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4477478..4479000 forward strand

Annotation

Protein features

Orthologs

• cut8 (SJAG_00054) Schizosaccharomyces japonicus
• STS1 (YIR011C) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Hirano T et al. EMBO J 1986 Nov;5(11):2973-9

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:16096059 - Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8.

Takeda K et al. Cell 2005 Aug 12;122(3):393-405

PMID:28545058 - A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.

Kume K et al. PLoS Genet 2017 May;13(5):e1006767

PMID:10582241 - Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.

Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 1999 Sep 29;354(1389):1559-69; discussion 1569-70

PMID:21976488 - Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.

Takeda K et al. Proc Natl Acad Sci U S A 2011 Oct 11;108(41):16950-5

PMID:39473973 - Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity.

Ruiz-Romero G et al. iScience 2024 Nov 15;27(11):111095

PMID:37694715 - A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis.

Le TK et al. J Cell Sci 2023 Oct 01;136(19)

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:8065367 - Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase.

Samejima I et al. Mol Cell Biol 1994 Sep;14(9):6361-71

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:11084332 - Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

Tatebe H et al. Curr Biol 2000 Nov 02;10(21):1329-38

PMID:12553909 - Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.

Yen HC et al. Cell 2003 Jan 24;112(2):207-17

PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.

Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:15161942 - The nucleolus is involved in mRNA export from the nucleus in fission yeast.

Ideue T et al. J Cell Sci 2004 Jun 15;117(Pt 14):2887-95

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:12006658 - Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.

Dunand-Sauthier I et al. Mol Biol Cell 2002 May;13(5):1626-40

PMID:26527280 - Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.

Kamenz J et al. Mol Cell 2015 Nov 05;60(3):446-59

PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.

Zemlianski V et al. J Cell Sci 2024 May 23;

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:17178839 - Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.

Kearsey SE et al. Mol Cell Biol 2007 Mar;27(5):1558-67

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.

PMID:21247416 - Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

Gatti L et al. BMC Genomics 2011 Jan 19;12:44

PMID:12653962 - A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.

Matsumura T et al. Genes Cells 2003 Apr;8(4):341-55

PMID:24710126 - The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin.

Kitagawa T et al. Nat Commun 2014 Apr 07;5:3597

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82

PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:21091378 - Txl1 and Txc1 are co-factors of the 26S proteasome in fission yeast.

Andersen KM et al. Antioxid Redox Signal 2011 May 01;14(9):1601-8