protein coding gene - cut8 (SPAC17C9.13c) - tethering factor for nuclear proteasome Cut8
Gene summary
- Standard name
- cut8
- Systematic ID
- SPAC17C9.13c
- Product
- tethering factor for nuclear proteasome Cut8
- Organism
- Schizosaccharomyces pombe
(fission yeast)
- UniProt ID
- P38937
- ORFeome ID
- 09/09H07
- Characterisation status
- biological role published
- Feature type
- mRNA gene
- Genomic location
- chromosome I: 4477478..4479000 forward strand
Annotation
Quantitative gene expression
Protein features
| ID | Name | InterPro name | DB name |
| PF08559 | Cut8 | Cut8/Sts1_fam | Pfam |
| G3DSA:1.20.58.1590 | | Cut8/Sts1_sf | CATH-Gene3D |
| PTHR28032 | | Cut8/Sts1_fam | PANTHER |
| Coil | | | COILS |
Orthologs
- cut8 (SJAG_00054) Schizosaccharomyces japonicus
- STS1 (YIR011C) Saccharomyces cerevisiae
References / Literature
- PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
- Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
- PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
- Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
- PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
- Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
- PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
- Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
- PMID:26527280 - Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.
- Kamenz J et al. Mol Cell 2015 Nov 05;60(3):446-59
- PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
- Skribbe M et al. Mol Cell 2025 Feb 19;
- PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.
- Hirano T et al. EMBO J 1986 Nov;5(11):2973-9
- PMID:21091378 - Txl1 and Txc1 are co-factors of the 26S proteasome in fission yeast.
- Andersen KM et al. Antioxid Redox Signal 2011 May 01;14(9):1601-8
- PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
- Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
- PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.
- Zemlianski V et al. J Cell Sci 2024 May 23;
- PMID:12553909 - Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.
- Yen HC et al. Cell 2003 Jan 24;112(2):207-17
- PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
- Han TX et al. Genome Biol 2010;11(6):R60
- PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.
- Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619
- PMID:17178839 - Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.
- Kearsey SE et al. Mol Cell Biol 2007 Mar;27(5):1558-67
- PMID:21247416 - Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
- Gatti L et al. BMC Genomics 2011 Jan 19;12:44
- PMID:28545058 - A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.
- Kume K et al. PLoS Genet 2017 May;13(5):e1006767
- PMID:21511999 - Comparative functional genomics of the fission yeasts.
- Rhind N et al. Science 2011 May 20;332(6032):930-6
- PMID:12653962 - A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.
- Matsumura T et al. Genes Cells 2003 Apr;8(4):341-55
- PMID:20133687 - Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.
- Takeda K et al. Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3540-5
- PMID:39473973 - Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity.
- Ruiz-Romero G et al. iScience 2024 Nov 15;27(11):111095
- PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.
- Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
- PMID:21976488 - Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.
- Takeda K et al. Proc Natl Acad Sci U S A 2011 Oct 11;108(41):16950-5
- PMID:11084332 - Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.
- Tatebe H et al. Curr Biol 2000 Nov 02;10(21):1329-38
- PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
- Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
- PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
- Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
- PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
- Hayles J et al. Open Biol 2013 May 22;3(5):130053
- PMID:24710126 - The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin.
- Kitagawa T et al. Nat Commun 2014 Apr 07;5:3597
- PMID:37694715 - A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis.
- Le TK et al. J Cell Sci 2023 Oct 01;136(19)
- PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
- Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
- PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
- Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
- PMID:15161942 - The nucleolus is involved in mRNA export from the nucleus in fission yeast.
- Ideue T et al. J Cell Sci 2004 Jun 15;117(Pt 14):2887-95
- PMID:8065367 - Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase.
- Samejima I et al. Mol Cell Biol 1994 Sep;14(9):6361-71
- PMID:12006658 - Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.
- Dunand-Sauthier I et al. Mol Biol Cell 2002 May;13(5):1626-40
- PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.
-
- GO_REF:0000033 - Annotation inferences using phylogenetic trees
-
- PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
- Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
- PMID:10582241 - Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.
- Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 1999 Sep 29;354(1389):1559-69; discussion 1569-70
- PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
- Takeda K et al. PLoS One 2011;6(7):e22021
- PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.
- Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82
- PMID:16096059 - Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8.
- Takeda K et al. Cell 2005 Aug 12;122(3):393-405
- PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
- Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
