protein coding gene - cpp1 (SPAC17G6.04c) - protein farnesyltransferase beta subunit Cpp1

Gene summary

Standard name

cpp1

Systematic ID

SPAC17G6.04c

Product

protein farnesyltransferase beta subunit Cpp1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O13782

ORFeome ID

18/18B06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3592994..3596406 reverse strand

Annotation

Protein features

Orthologs

• FNTB (HGNC:3785) Homo sapiens
• CHURC1-FNTB (HGNC:42960) Homo sapiens
• cpp1 (SJAG_02583) Schizosaccharomyces japonicus
• RAM1 (YDL090C) Saccharomyces cerevisiae

References / Literature

PMID:10617635 - Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.

Yang W et al. J Biol Chem 2000 Jan 07;275(1):429-38

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25500221 - Balance between exocytosis and endocytosis determines the efficacy of sterol-targeting antibiotics.

Nishimura S et al. Chem Biol 2014 Dec 18;21(12):1690-9

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

Nakase Y et al. Genetics 2006 Jun;173(2):569-78

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:30959830 - Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation.

González-Rubio G et al. Int J Mol Sci 2019 Apr 05;20(7)

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.

Navarro FJ et al. Genome Biol 2012 May 24;13(5):R36

PMID:20847589 - Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis.

Imagawa K et al. Kobe J Med Sci 2009 Jun 05;55(2):E30-5

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21849474 - Spatial control of Cdc42 activation determines cell width in fission yeast.

Kelly FD et al. Mol Biol Cell 2011 Oct;22(20):3801-11

PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Murai T et al. Genetics 2009 Oct;183(2):517-27

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:17005909 - Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.

Ma Y et al. Mol Biol Cell 2006 Dec;17(12):5028-37

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:8665904 - Enzymic characterization of fission yeast farnesyl transferase: recognition of the -CAAL motif at the C-terminus.

Danjoh I et al. Eur J Biochem 1996 Mar 15;236(3):847-51