protein coding gene - pep7 (SPAC17G6.08) - prevacuole/endosomal FYVE tethering component Pep7

Gene summary

Standard name: pep7
Systematic ID: SPAC17G6.08
Product: prevacuole/endosomal FYVE tethering component Pep7
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: vac1
UniProt ID: O13786
ORFeome ID: 25/25H01
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 3601717..3603904 forward strand

Annotation

Disease association

MONDO:0014118 - congenital neutropenia-myelofibrosis-nephromegaly syndrome

References:

PB_REF:0000003

MONDO:0975795 - Kariminejad neurodevelopmental syndrome

References:

PB_REF:0000006

MONDO:0975797 - myelofibrosis, congenital, with anemia, neutropenia, developmental delay, and ocular abnormalities

References:

PB_REF:0000006

GO biological process

GO:0006896 - Golgi to vacuole transport

References:

GO_REF:0000024

GO:0006906 - vesicle fusion

References:

GO_REF:0000024

GO cellular component

GO:0005737 - cytoplasm

References:

PMID:16823372

GO:0010009 - cytoplasmic side of endosome membrane

References:

GO_REF:0000024

GO:0005794 - Golgi apparatus

References:

PMID:16823372

GO molecular function

GO:0046872 - metal ion binding

References:

GO_REF:0000002

GO:0032266 - phosphatidylinositol-3-phosphate binding

References:

GO_REF:0000024

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

PMID:25720772

Protein features

PBO:0111745 - zf-C2H2 type

PBO:0111867 - zf-FYVE type

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PMID:16537923

PomGeneEx:0000011 - RNA level increased

References:

PMID:12161753

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000250 - decreased cell population growth on proline nitrogen source

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009097 - decreased cell population growth on xylose carbon source

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000708 - decreased mating efficiency

References:

PMID:23950735

Genotypes:

pep7delta

FYPO:0000245 - loss of viability in stationary phase

References:

PMID:24463365

Genotypes:

pep7delta

FYPO:0000067 - resistance to brefeldin A

References:

Genotypes:

pep7delta

FYPO:0000073 - resistance to caffeine

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0003824 - resistance to caffeine and rapamycin

References:

PMID:24463365

Genotypes:

pep7delta

FYPO:0000764 - resistance to cycloheximide

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0002693 - resistance to diamide

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009038 - resistance to egtazic acid

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0001453 - resistance to ethanol

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009035 - resistance to formamide

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0005193 - resistance to torin1

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000830 - resistance to vanadate

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009067 - sensitive to amorolfine

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000095 - sensitive to bleomycin

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000096 - sensitive to cadmium

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000087 - sensitive to hydrogen peroxide

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0001719 - sensitive to lithium

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0001214 - sensitive to potassium chloride

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0001457 - sensitive to tunicamycin

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0000115 - sensitive to valproic acid

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0003656 - sensitive to vanadate

References:

PMID:37787768

Genotypes:

pep7delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

pep7delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

pep7delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01363	FYVE	Znf_FYVE	PFAM
PF11464	Rbsn	Rbsn_Rab-bd	PFAM
cd15761	FYVE1_Vac1p_like		CDD
PS00028	ZINC_FINGER_C2H2_1	Znf_C2H2_type	PROSITE_PATTERNS
PS50178	ZF_FYVE	Znf_FYVE-rel	PROSITE_PROFILES
SM00064	fyve_4	Znf_FYVE	SMART
SSF140125	Rabenosyn-5 Rab-binding domain-like	Rbsn_Rab-bd_sf	SUPERFAMILY
SSF57903	FYVE/PHD zinc finger	Znf_FYVE_PHD	SUPERFAMILY
G3DSA:3.30.40.10	Zinc/RING finger domain, C3HC4 (zinc finger)	Znf_RING/FYVE/PHD	GENE3D
G3DSA:4.10.860.20	Rabenosyn, Rab binding domain		GENE3D
PTHR13510	FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED	Rab4/Rab5_effector	PANTHER
Coil	Coil		COILS
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polar	disorder_prediction		MOBIDB-Polar

Orthologs

RBSN (HGNC:20759) Homo sapiens
pep7 (SJAG_02587) Schizosaccharomyces japonicus
PEP7 (YDR323C) Saccharomyces cerevisiae

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000003 - Disease Association Curation
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.: Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.: Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000002 - Comments
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.: Sun LL et al. PLoS Genet 2013;9(8):e1003715