protein coding gene - cul1 (SPAC17G6.12) - cullin 1

Gene summary

Standard name

cul1

Systematic ID

SPAC17G6.12

Product

cullin 1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

pcu1

UniProt ID

O13790

ORFeome ID

47/47B10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 3612057..3614883 forward strand

Annotation

Protein features

Orthologs

• CUL1 (HGNC:2551) Homo sapiens
• cul1 (SJAG_02591) Schizosaccharomyces japonicus
• CDC53 (YDL132W) Saccharomyces cerevisiae

References / Literature

PMID:12167173 - Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p.

Seibert V et al. BMC Biochem 2002 Aug 07;3:22

PMID:11337588 - Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

Lyapina S et al. Science 2001 May 18;292(5520):1382-5

PMID:23496905 - Nedd8 processing enzymes in Schizosaccharomyces pombe.

O'Donoghue JE et al. BMC Biochem 2013 Mar 15;14:8

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:25165823 - Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

Tsutsui Y et al. PLoS Genet 2014 Aug;10(8):e1004542

PMID:19748355 - F-box-directed CRL complex assembly and regulation by the CSN and CAND1.

Schmidt MW et al. Mol Cell 2009 Sep 11;35(5):586-97

PMID:11854407 - Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes.

Mundt KE et al. Mol Biol Cell 2002 Feb;13(2):493-502

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:32047038 - Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.

Lin H et al. Proc Natl Acad Sci U S A 2020 Feb 25;117(8):4117-4124

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:11809834 - Fission yeast F-box protein Pof3 is required for genome integrity and telomere function.

Katayama S et al. Mol Biol Cell 2002 Jan;13(1):211-24

PMID:17016471 - Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.

Tafforeau L et al. EMBO J 2006 Oct 04;25(19):4547-56

PMID:15769255 - Nep1, a Schizosaccharomyces pombe deneddylating enzyme.

Zhou L et al. Biochem J 2005 Jul 15;389(Pt 2):307-14

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:9990507 - Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase.

Kominami K et al. Genes Cells 1998 Nov;3(11):721-35

PMID:15555586 - Mcs2 and a novel CAK subunit Pmh1 associate with Skp1 in fission yeast.

Bamps S et al. Biochem Biophys Res Commun 2004 Dec 24;325(4):1424-32

PMID:29149173 - Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire.

Straube R et al. PLoS Comput Biol 2017 Nov;13(11):e1005869

PMID:38285941 - Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance.

Nathanailidou P et al. Proc Natl Acad Sci U S A 2024 Feb 06;121(6):e2315596121

PMID:15660136 - SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast.

Harrison C et al. EMBO J 2005 Feb 09;24(3):599-610

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:12183637 - Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

Cope GA et al. Science 2002 Oct 18;298(5593):608-11

PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Lehmann A et al. Genes Cells 2004 May;9(5):367-82

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10880460 - Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.

Osaka F et al. EMBO J 2000 Jul 03;19(13):3475-84

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:23535663 - CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.

Wu S et al. Nat Commun 2013;4:1642