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protein coding gene - trl1 (SPAC17G8.01c) - tRNA ligase Trl1

Gene summary

Standard name
trl1
Systematic ID
SPAC17G8.01c
Product
tRNA ligase Trl1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC6C3.10c
UniProt ID
Q10313
ORFeome ID
52/52B07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2341251..2343988 reverse strand

Annotation

GO biological process

GO:0006388 - tRNA splicing, via endonucleolytic cleavage and ligation

References:

GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

References:

GO:0005524 - ATP binding

References:

GO:0051730 - GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity

References:

GO:0003972 - RNA ligase (ATP) activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000108 - frameshifted

References:

PBO:0091382 - I:g.2343703_2343704insA

References:

PBO:0000129 - sequence error in genomic data

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Protein features

IDNameInterPro nameDB name
PF08302tRNA_lig_CPDtRNA_lig_PDEasePfam
PF08303tRNA_lig_kinasetRNA_lig_kin_fungiPfam
PF09511RNA_lig_T4_1T4-Rnl1-like_NPfam
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR32004PANTHER
PIRSF019634tRNA_lig_yeastTrl1_funPIRSF

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26615217 - Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.
Hu W et al. Genome Biol Evol 2015 Nov 27;7(12):3496-510
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000002 - Comments
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.