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protein coding gene - urh2 (SPAC17G8.02) - uridine ribohydrolase Urh2

Gene summary

Standard name
urh2
Systematic ID
SPAC17G8.02
Product
uridine ribohydrolase Urh2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10314
ORFeome ID
14/14E01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2344521..2346044 forward strand

Annotation

GO biological process

GO:0034355 - NAD+ biosynthetic process via the salvage pathway

References:

GO:0019358 - nicotinate nucleotide salvage

References:

GO:0046135 - pyrimidine nucleoside catabolic process

References:

GO:0008655 - pyrimidine-containing compound salvage

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0070635 - nicotinamide riboside hydrolase activity

References:

GO:0070636 - nicotinic acid riboside hydrolase activity

References:

GO:0045437 - uridine nucleosidase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01149 - sumoylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01156IU_nuc_hydroInosine/uridine_hydrolase_domPfam
cd02651nuc_hydro_IU_UC_XIUACDD
PS01247IUNHI/U_nuclsd_hydro_CSPROSITE patterns
G3DSA:3.90.245.10Ribo_hydro-likeCATH-Gene3D
SSF53590Ribo_hydro-likeSUPERFAMILY
PTHR12304IUNHPANTHER

Orthologs

References / Literature

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:35940128 - Queuosine salvage in fission yeast by Qng1-mediated hydrolysis to queuine.
Patel BI et al. Biochem Biophys Res Commun 2022 Oct 08;624:146-150
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827