protein coding gene - arc5 (SPAC17G8.04c) - ARP2/3 actin-organizing complex subunit Arc5

Gene summary

Standard name

arc5

Systematic ID

SPAC17G8.04c

Product

ARP2/3 actin-organizing complex subunit Arc5

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

arc15

UniProt ID

Q10316

ORFeome ID

08/08E06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2348292..2349324 reverse strand

Annotation

Protein features

Orthologs

• ARPC5L (HGNC:23366) Homo sapiens
• ARPC5 (HGNC:708) Homo sapiens
• arc5 (SJAG_04100) Schizosaccharomyces japonicus
• ARC15 (YIL062C) Saccharomyces cerevisiae

References / Literature

PMID:20517925 - GMF is an evolutionarily developed Adf/cofilin-super family protein involved in the Arp2/3 complex-mediated organization of the actin cytoskeleton.

Nakano K et al. Cytoskeleton (Hoboken) 2010 Jun;67(6):373-82

GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:25040903 - Eng2 is a component of a dynamic protein complex required for endocytic uptake in fission yeast.

Encinar del Dedo J et al. Traffic 2014 Oct;15(10):1122-42

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12214236 - Actin dynamics in the contractile ring during cytokinesis in fission yeast.

Pelham RJ et al. Nature 2002 Sep 05;419(6902):82-6

GO_REF:0000002 - Comments

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:38448439 - Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex.

Chavali SS et al. Nat Commun 2024 Mar 06;15(1):2059

PMID:16087707 - Interactions of WASp, myosin-I, and verprolin with Arp2/3 complex during actin patch assembly in fission yeast.

Sirotkin V et al. J Cell Biol 2005 Aug 15;170(4):637-48

PMID:20587778 - Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.

Sirotkin V et al. Mol Biol Cell 2010 Aug 15;21(16):2894-904

PMID:25825517 - A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.

Dudin O et al. J Cell Biol 2015 Mar 30;208(7):897-911

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:21620704 - Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis.

Basu R et al. Curr Biol 2011 Jun 07;21(11):905-16

PMID:36442092 - Mechanism of actin filament branch formation by Arp2/3 complex revealed by a high-resolution cryo-EM structureof the branch junction.

Chou SZ et al. Proc Natl Acad Sci U S A 2022 Dec 06;119(49):e2206722119

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:32839613 - Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state.

Shaaban M et al. Nat Struct Mol Biol 2020 Nov;27(11):1009-1016

PMID:19362000 - Cofilin dissociates Arp2/3 complex and branches from actin filaments.

Chan C et al. Curr Biol 2009 Apr 14;19(7):537-45

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.

Wu JQ et al. Science 2005 Oct 14;310(5746):310-4

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18165685 - Pathway of actin filament branch formation by Arp2/3 complex.

Beltzner CC et al. J Biol Chem 2008 Mar 14;283(11):7135-44

PMID:18640983 - Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit.

Nolen BJ et al. J Biol Chem 2008 Sep 26;283(39):26490-8

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:41850284 - Arp2/3-dependent actin assembly shapes endosomes and promotes intracellular trafficking in fission yeast.

Melero A et al. Curr Biol 2026 Mar 17;

PMID:21642440 - Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.

Skau CT et al. J Biol Chem 2011 Jul 29;286(30):26964-77

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9