protein coding gene - dma1 (SPAC17G8.10c) - mitotic spindle checkpoint ubiquitin ligase Dma1

Gene summary

Standard name

dma1

Systematic ID

SPAC17G8.10c

Product

mitotic spindle checkpoint ubiquitin ligase Dma1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q10322

ORFeome ID

10/10B10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2358028..2359871 reverse strand

Annotation

Protein features

Orthologs

• RNF8 (HGNC:10071) Homo sapiens
• dma1 (SJAG_02169) Schizosaccharomyces japonicus
• DMA1 (YHR115C) Saccharomyces cerevisiae
• DMA2 (YNL116W) Saccharomyces cerevisiae

References / Literature

PMID:30600396 - Spatiotemporal regulation of the Dma1-mediated mitotic checkpoint coordinates mitosis with cytokinesis.

Cullati SN et al. Curr Genet 2019 Jun;65(3):663-668

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:10769201 - The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation.

Salimova E et al. J Cell Sci 2000 May;113 ( Pt 10):1695-704

PMID:29742018 - The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole.

Elmore ZC et al. Mol Biol Cell 2018 Jul 01;29(13):1664-1674

PMID:12479804 - Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).

Guertin DA et al. Dev Cell 2002 Dec;3(6):779-90

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:10924454 - A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast.

Cullen CF et al. Genetics 2000 Aug;155(4):1521-34

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:37463013 - Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro.

Jacobsen NL et al. Protein Sci 2023 Sep;32(9):e4733

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:23549175 - RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures.

Chahwan R et al. Cell Cycle 2013 Apr 15;12(8):1161-2

PMID:24055157 - CK1 is required for a mitotic checkpoint that delays cytokinesis.

Johnson AE et al. Curr Biol 2013 Oct 07;23(19):1920-6

PMID:8978687 - The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised.

Murone M et al. EMBO J 1996 Dec 02;15(23):6605-16

PMID:24838944 - Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe.

Krapp A et al. J Cell Sci 2014 Jul 15;127(Pt 14):3149-61

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:28178520 - Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.

Meadows JC et al. Cell Rep 2017 Feb 07;18(6):1422-1433

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:20826461 - The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis.

Krapp A et al. J Cell Sci 2010 Oct 01;123(Pt 19):3284-93

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:21247416 - Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

Gatti L et al. BMC Genomics 2011 Jan 19;12:44

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21131906 - Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.

Johnson AE et al. EMBO J 2011 Jan 19;30(2):341-54

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:22809626 - Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast.

Wang Y et al. Mol Biol Cell 2012 Sep;23(17):3348-56

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:36138017 - Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress.

Wang X et al. Nat Commun 2022 Sep 22;13(1):5565

PMID:22669973 - Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function.

Johnson AE et al. J Biol Chem 2012 Jul 27;287(31):25741-8

PMID:29975113 - Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization.

Jones CM et al. Mol Biol Cell 2018 Sep 01;29(18):2176-2189

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:11069763 - Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast.

Pidoux AL et al. J Cell Sci 2000 Dec;113 Pt 23:4177-91

PMID:39471327 - New mutations in the core Schizosaccharomyces pombe spindle pole body scaffold Ppc89 reveal separable functions in regulating cell division.

Hanna SM et al. G3 (Bethesda) 2024 Oct 29;

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:23442799 - Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins.

Chahwan R et al. Cell Cycle 2013 Mar 15;12(6):1000-8

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:20980623 - A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast.

Li WZ et al. Mol Biol Cell 2010 Dec;21(24):4349-60

PMID:11271422 - Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes.

Fournier N et al. Arch Microbiol 2001 Jan;175(1):62-9

PMID:18225957 - Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.

Chew TG et al. PLoS Genet 2008 Jan;4(1):e17

PMID:34674264 - Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation.

Chen JS et al. FEBS Lett 2021 Nov;595(22):2781-2792

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6