protein coding gene - pck1 (SPAC17G8.14c) - protein kinase C (PKC)-like Pck1

Gene summary

Standard name

pck1

Systematic ID

SPAC17G8.14c

Product

protein kinase C (PKC)-like Pck1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPAC22H10.01c

UniProt ID

P36582

ORFeome ID

30/30B06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2367140..2370612 reverse strand

Annotation

Protein features

Orthologs

• PRKCA (HGNC:9393) Homo sapiens
• PRKCB (HGNC:9395) Homo sapiens
• PRKCD (HGNC:9399) Homo sapiens
• PRKCE (HGNC:9401) Homo sapiens
• PRKCH (HGNC:9403) Homo sapiens
• PRKCQ (HGNC:9410) Homo sapiens
• pck1 (SJAG_01787) Schizosaccharomyces japonicus
• PKC1 (YBL105C) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:28536259 - Differential functional regulation of protein kinase C (PKC) orthologs in fission yeast.

Madrid M et al. J Biol Chem 2017 Jul 07;292(27):11374-11387

PMID:10504305 - Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.

Arellano M et al. J Cell Sci 1999 Oct;112 ( Pt 20):3569-78

PMID:17005909 - Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.

Ma Y et al. Mol Biol Cell 2006 Dec;17(12):5028-37

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:15923187 - Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway.

Deng L et al. J Biol Chem 2005 Jul 29;280(30):27561-8

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:34910579 - Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis.

Longo LVG et al. Mol Biol Cell 2022 Feb 01;33(2):ar17

PMID:28264193 - Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.

Tatebe H et al. Elife 2017 Mar 07;6

PMID:23294323 - The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.

Cadou A et al. Biol Cell 2013 Mar;105(3):129-48

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model

PMID:19486165 - Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.

Fang Y et al. Genes Cells 2009 Jun;14(6):759-71

PMID:25416816 - Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.

Madrid M et al. J Cell Sci 2015 Jan 15;128(2):266-80

PMID:8387356 - Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

Shimanuki M et al. Mol Biol Cell 1993 Mar;4(3):303-13

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:9199286 - Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe.

Sengar AS et al. Mol Cell Biol 1997 Jul;17(7):3508-19

PMID:34666001 - Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.

Neeli-Venkata R et al. Dev Cell 2021 Oct 25;56(20):2856-2870.e7

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:11102532 - Schizosaccharomyces pombe rho2p GTPase regulates cell wall alpha-glucan biosynthesis through the protein kinase pck2p.

Calonge TM et al. Mol Biol Cell 2000 Dec;11(12):4393-401

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:21832151 - Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.

Kashiwazaki J et al. Mol Biol Cell 2011 Oct;22(19):3658-70

PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.

Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:10087262 - Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.

Katayama S et al. J Cell Biol 1999 Mar 22;144(6):1173-86

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:8886983 - The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Toda T et al. J Cell Sci 1996 Sep;109 ( Pt 9):2331-42

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:37746062 - Polarity kinases that phosphorylate F-BAR protein Cdc15 have unique localization patterns during cytokinesis and contributions to preventing tip septation in Schizosaccharomyces pombe .

Igarashi MG et al. MicroPubl Biol 2023;2023

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:15548596 - Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.

Webb CJ et al. Mol Biol Cell 2005 Feb;16(2):584-96

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:11016847 - Schizosaccharomyces pombe ehs1p is involved in maintaining cell wall integrity and in calcium uptake.

Carnero E et al. Mol Gen Genet 2000 Sep;264(1-2):173-83

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:37792890 - Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.

Willet AH et al. PLoS Genet 2023 Oct;19(10):e1010987

PMID:8943330 - The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway.

Toda T et al. Mol Cell Biol 1996 Dec;16(12):6752-64

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

PMID:7929623 - Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control.

Kobori H et al. J Cell Sci 1994 May;107 ( Pt 5):1131-6

PMID:14625898 - Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.

Gräub R et al. J Basic Microbiol 2003;43(6):473-82

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:12519200 - Rga5p is a specific Rho1p GTPase-activating protein that regulates cell integrity in Schizosaccharomyces pombe.

Calonge TM et al. Mol Microbiol 2003 Jan;47(2):507-18

PMID:20624220 - Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.

Cadou A et al. Mol Microbiol 2010 Sep;77(5):1186-202

PMID:18653539 - Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast.

Low CP et al. J Cell Sci 2008 Aug 15;121(Pt 16):2671-84

PMID:16421249 - Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.

García P et al. Mol Biol Cell 2006 Apr;17(4):1620-31

PMID:25651781 - Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.

Doi A et al. Genes Cells 2015 Apr;20(4):310-23

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23907979 - The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.

Cruz S et al. Microbiologyopen 2013 Oct;2(5):778-94

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:34198697 - Specific Functional Features of the Cell Integrity MAP Kinase Pathway in the Dimorphic Fission Yeast Schizosaccharomyces japonicus .

Gómez-Gil E et al. J Fungi (Basel) 2021 Jun 14;7(6)

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:10651902 - Rho-dependence of Schizosaccharomyces pombe Pck2.

Sayers LG et al. Genes Cells 2000 Jan;5(1):17-27

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:24498240 - Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.

Sánchez-Mir L et al. PLoS One 2014;9(1):e88020

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:28914606 - Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.

McDonald NA et al. Elife 2017 Sep 15;6

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:36749320 - Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.

Bhattacharjee R et al. Elife 2023 Feb 07;12

PMID:11737264 - Characterization of GTPase-activating proteins for the function of the Rho-family small GTPases in the fission yeast Schizosaccharomyces pombe.

Nakano K et al. Genes Cells 2001 Dec;6(12):1031-42

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:8491190 - Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control.

Toda T et al. EMBO J 1993 May;12(5):1987-95

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:8463273 - A Ca(2+)-independent protein kinase C from fission yeast.

Mazzei GJ et al. J Biol Chem 1993 Apr 05;268(10):7401-6

PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.

Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12