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protein coding gene - wip1 (SPAC17G8.15) - CENP-W ortholog

Gene summary

Standard name
wip1
Systematic ID
SPAC17G8.15
Product
CENP-W ortholog
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
new1
UniProt ID
G2TRL2
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2348008..2348451 forward strand

Annotation

GO biological process

GO:0051382 - kinetochore assembly

References:

GO:0000070 - mitotic sister chromatid segregation

References:

GO cellular component

GO:0061838 - CENP-T-W-S-X complex

References:

GO:0000776 - kinetochore

References:

GO:0005654 - nucleoplasm

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0001946 - abolished mitotic sister chromatid separation

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

References:

Genotypes:

FYPO:0000283 - mitotic chromosome fragmentation upon segregation

References:

Genotypes:

FYPO:0000276 - monopolar mitotic spindle

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF00808CBFD_NFYB_HMFCBFA_NFYB_domainPFAM
cd13732HFD_CENP-WCDD
G3DSA:1.10.20.10:FF:000075FUNFAM
SSF47113Histone-foldHistone-foldSUPERFAMILY
G3DSA:1.10.20.10Histone, subunit AHistone-foldGENE3D
PTHR34832CENTROMERE PROTEIN WCENP-W/WIP1PANTHER

Orthologs

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:34810257 - Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.
Dong Q et al. Proc Natl Acad Sci U S A 2021 Nov 30;118(48)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22561346 - CENP-T proteins are conserved centromere receptors of the Ndc80 complex.
Schleiffer A et al. Nat Cell Biol 2012 May 06;14(6):604-13
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6