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protein coding gene - cid16 (SPAC17H9.01) - poly(A/U) polymerase Cid16

Gene summary

Standard name
cid16
Systematic ID
SPAC17H9.01
Product
poly(A/U) polymerase Cid16
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13798
ORFeome ID
48/48E01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2000725..2004811 forward strand

Annotation

GO biological process

GO:0000957 - mitochondrial RNA catabolic process

References:

GO:1990074 - polyuridylation-dependent mRNA catabolic process

References:

GO:0140746 - siRNA catabolic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO molecular function

GO:0050265 - RNA uridylyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Multi-locus phenotype

FYPO:0008339 - abolished 3' end uridylation of non-polyadenylated RNA

References:

Genotypes:

FYPO:0008336 - abolished mRNA poly(A) tail uridylation

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0008337 - decreased 3' end uridylation of non-polyadenylated RNA

References:

Genotypes:

FYPO:0004201 - decreased centromeric outer repeat transcript-derived siRNA level

References:

Genotypes:

FYPO:0000888 - decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

References:

Genotypes:

FYPO:0006073 - decreased small RNA degradation

References:

Genotypes:

FYPO:0000220 - increased centromeric outer repeat transcript level

References:

Genotypes:

FYPO:0006995 - normal chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF22600MTPAP-like_centralMTPAP-like_centralPFAM
cd05402NT_PAP_TUTaseCDD
G3DSA:3.30.460.10:FF:000067FUNFAM
SSF81631PAP/OAS1 substrate-binding domainSUPERFAMILY
SSF81301NucleotidyltransferaseNT_sfSUPERFAMILY
G3DSA:1.10.1410.10GENE3D
G3DSA:3.30.460.10Beta Polymerase, domain 2NT_sfGENE3D
PTHR12271POLY A POLYMERASE CID PAP -RELATEDPANTHER

Orthologs

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:22139915 - The telomeric transcriptome of Schizosaccharomyces pombe.
Bah A et al. Nucleic Acids Res 2012 Apr;40(7):2995-3005
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28541282 - Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.
Pisacane P et al. Nat Commun 2017 May 25;8:15332
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:17512405 - RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing.
Bühler M et al. Cell 2007 May 18;129(4):707-21
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39333464 - Uridylation regulates mRNA decay directionality in fission yeast.
Grochowski M et al. Nat Commun 2024 Sep 27;15(1):8359