protein coding gene - ras1 (SPAC17H9.09c) - GTPase Ras1

Gene summary

Standard name

ras1

Systematic ID

SPAC17H9.09c

Product

GTPase Ras1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

ste5

UniProt ID

P08647

ORFeome ID

43/43A06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2019462..2020631 reverse strand

Annotation

Protein features

Orthologs

• HRAS (HGNC:5173) Homo sapiens
• KRAS (HGNC:6407) Homo sapiens
• NRAS (HGNC:7989) Homo sapiens
• ras1 (SJAG_03453) Schizosaccharomyces japonicus
• RAS2 (YNL098C) Saccharomyces cerevisiae
• RAS1 (YOR101W) Saccharomyces cerevisiae

References / Literature

PMID:9892665 - Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation.

Chen CR et al. Proc Natl Acad Sci U S A 1999 Jan 19;96(2):517-22

PMID:37788281 - A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.

Ohshima T et al. PLoS One 2023;18(10):e0291524

PB_REF:0000003 - Disease Association Curation

PMID:14665462 - Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated.

Tanabe K et al. Eukaryot Cell 2003 Dec;2(6):1274-87

PMID:9509424 - Isolation of synthetic lethal mutants of ras1 in Schizosaccharomyces pombe.

Chung KS et al. Mol Cells 1997 Dec 31;7(6):800-6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:8682866 - A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis.

Song K et al. J Cell Biol 1996 Jun;133(6):1307-19

PMID:16322512 - zds1, a novel gene encoding an ortholog of Zds1 and Zds2, controls sexual differentiation, cell wall integrity and cell morphology in fission yeast.

Yakura M et al. Genetics 2006 Feb;172(2):811-25

PMID:1883874 - sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

Wang Y et al. Cell Regul 1991 Jun;2(6):453-65

PMID:10395922 - Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe.

Kawamukai M Biochim Biophys Acta 1999 Jul 07;1446(1-2):93-101

PMID:9315645 - Multiple regulatory domains on the Byr2 protein kinase.

Tu H et al. Mol Cell Biol 1997 Oct;17(10):5876-87

PMID:9524252 - Isolation of a novel heat shock protein 70-like gene, pss1+ of Schizosaccharomyces pombe homologous to hsp110/SSE subfamily.

Chung KS et al. Gene 1998 Mar 27;210(1):143-50

PMID:9745019 - ras1 and pat1 alleles interact to quantitatively and qualitatively alter conjugation in fission yeast.

Mach KE et al. Curr Genet 1998 Sep;34(3):172-82

PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34

PMID:21849474 - Spatial control of Cdc42 activation determines cell width in fission yeast.

Kelly FD et al. Mol Biol Cell 2011 Oct;22(20):3801-11

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:10504305 - Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.

Arellano M et al. J Cell Sci 1999 Oct;112 ( Pt 20):3569-78

PMID:10567532 - Direct binding and In vivo regulation of the fission yeast p21-activated kinase shk1 by the SH3 domain protein scd2.

Chang E et al. Mol Cell Biol 1999 Dec;19(12):8066-74

PMID:2107403 - Homologous activators of ras in fission and budding yeast.

Hughes DA et al. Nature 1990 Mar 22;344(6264):355-7

PMID:10436025 - Fission yeast Pob1p, which is homologous to budding yeast Boi proteins and exhibits subcellular localization close to actin patches, is essential for cell elongation and separation.

Toya M et al. Mol Biol Cell 1999 Aug;10(8):2745-57

GO_REF:0000003 - Gene Ontology annotation based on Enzyme Commission mapping

PMID:3071741 - Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1-.

Fukui Y et al. Mol Gen Genet 1988 Dec;215(1):26-31

PMID:7923372 - Cooperative interaction of S. pombe proteins required for mating and morphogenesis.

Chang EC et al. Cell 1994 Oct 07;79(1):131-41

PMID:34523683 - Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.

Rich-Robinson J et al. J Cell Sci 2021 Oct 01;134(19)

PMID:8943016 - The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

Gilbreth M et al. Proc Natl Acad Sci U S A 1996 Nov 26;93(24):13802-7

PMID:2586528 - Characterization of the Schizosaccharomyces pombe ral2 gene implicated in activation of the ras1 gene product.

Fukui Y et al. Mol Cell Biol 1989 Dec;9(12):5617-22

PMID:8443406 - Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.

Neiman AM et al. Mol Biol Cell 1993 Jan;4(1):107-20

PMID:1849107 - Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Hoffman CS et al. Genes Dev 1991 Apr;5(4):561-71

PMID:10835385 - Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

Mach KE et al. Genetics 2000 Jun;155(2):611-22

PMID:1515675 - A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Biol Cell 1992 Jul;3(7):721-34

PMID:12242289 - The 14-3-3 proteins Rad24 and Rad25 negatively regulate Byr2 by affecting its localization in Schizosaccharomyces pombe.

Ozoe F et al. Mol Cell Biol 2002 Oct;22(20):7105-19

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:8763147 - Changes in cell wall composition of deformed ras1- cells of Schizosaccharomyces pombe.

Harmouch N et al. Folia Microbiol (Praha) 1995;40(5):519-27

PMID:2046669 - byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

Wang Y et al. Mol Cell Biol 1991 Jul;11(7):3554-63

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:7483844 - Biochemical similarity of Schizosaccharomyces pombe ras1 protein with RAS2 protein of Saccharomyces cervisiae.

Onozawa T et al. Yeast 1995 Jul;11(9):801-8

PMID:16754851 - Compartmentalized signaling of Ras in fission yeast.

Onken B et al. Proc Natl Acad Sci U S A 2006 Jun 13;103(24):9045-50

PMID:2038319 - Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe.

Imai Y et al. Mol Cell Biol 1991 Jun;11(6):3088-94

PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38

PMID:10617635 - Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.

Yang W et al. J Biol Chem 2000 Jan 07;275(1):429-38

PMID:8816472 - Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

Barr MM et al. Mol Cell Biol 1996 Oct;16(10):5597-603

PMID:24147005 - The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis.

Weston C et al. PLoS One 2013;8(10):e77487

PMID:9133664 - The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.

Hakuno F et al. Genes Cells 1996 Mar;1(3):303-15

PMID:9514947 - The Byr2 kinase translocates to the plasma membrane in a Ras1-dependent manner.

Bauman P et al. Biochem Biophys Res Commun 1998 Mar 17;244(2):468-74

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:3002633 - Role of a ras homolog in the life cycle of Schizosaccharomyces pombe.

Fukui Y et al. Cell 1986 Jan 31;44(2):329-36

PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.

PMID:11461899 - Isolation of a novel gene from Schizosaccharomyces pombe: stm1+ encoding a seven-transmembrane loop protein that may couple with the heterotrimeric Galpha 2 protein, Gpa2.

Chung KS et al. J Biol Chem 2001 Oct 26;276(43):40190-201

PMID:23447405 - Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe.

Bond M et al. Yeast 2013 Apr;30(4):145-56

PMID:36650056 - Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe .

Pham TV et al. Life Sci Alliance 2023 Apr;6(4)

PMID:1563351 - The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription.

Nielsen O et al. EMBO J 1992 Apr;11(4):1391-5

PMID:7836423 - Protein kinase Byr2 is a target of Ras1 in the fission yeast Schizosaccharomyces pombe.

Masuda T et al. J Biol Chem 1995 Feb 03;270(5):1979-82

PMID:12052869 - Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors.

Papadaki P et al. Mol Cell Biol 2002 Jul;22(13):4598-606

PMID:29453312 - Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating.

Merlini L et al. J Cell Biol 2018 Apr 02;217(4):1467-1483

PMID:38449372 - Regulation of sexual differentiation initiation in Schizosaccharomyces pombe.

Kawamukai M Biosci Biotechnol Biochem 2024 Mar 06;

PMID:14573463 - Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis.

Li Y et al. Genetics 2003 Oct;165(2):477-88

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:1934121 - Pheromone production and response in sterile mutants of fission yeast.

Leupold U et al. Curr Genet 1991 Jul;20(1-2):79-85

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:8804400 - The G protein beta subunit Gpb1 of Schizosaccharomyces pombe is a negative regulator of sexual development.

Kim DU et al. Mol Gen Genet 1996 Aug 27;252(1-2):20-32

PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhang L et al. PLoS One 2013;8(7):e68738

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:12553909 - Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.

Yen HC et al. Cell 2003 Jan 24;112(2):207-17

PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.

Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905

PMID:17346842 - Yeast-based screening to identify modulators of G-protein signaling using uncontrolled cell division cycle by overexpression of Stm1.

Chung KS et al. J Biotechnol 2007 May 01;129(3):547-54

PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333

PMID:11709167 - Solution structure of the Ras binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe.

Gronwald W et al. Structure 2001 Nov;9(11):1029-41

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11121040 - Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation.

Yen HC et al. Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14370-5

PMID:3042386 - A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.

Nadin-Davis SA et al. EMBO J 1988 Apr;7(4):985-93

PMID:1863602 - Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe.

Kawamukai M et al. Cell Regul 1991 Feb;2(2):155-64

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:3481018 - Mapping of the ras1 gene of Schizosaccharomyces pombe.

Lund PM et al. Mol Gen Genet 1987 Oct;209(3):627-9

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:37528789 - [Inactivation of Ras1 in Fission Yeast Aggravates the Oxidative Stress Response Induced by Tert Butyl Hydroperoxide (tBHP)].

Masood N et al. Mol Biol (Mosk) 2023;57(4):689-691

PMID:15277777 - Interaction between a negative regulator (Msa2/Nrd1) and a positive regulator (Cpc2) of sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Biosci Biotechnol Biochem 2004 Jul;68(7):1621-6

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.

Sieber B et al. Nat Commun 2026 Mar 17;

PMID:7597098 - Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.

Marcus S et al. Proc Natl Acad Sci U S A 1995 Jun 20;92(13):6180-4

PMID:16273369 - Moc3, a novel Zn finger type protein involved in sexual development, ascus formation, and stress response of Schizosaccharomyces pombe.

Goldar MM et al. Curr Genet 2005 Dec;48(6):345-55

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:2300054 - Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.

Nadin-Davis SA et al. Mol Cell Biol 1990 Feb;10(2):549-60

PMID:23843742 - Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.

Zhang MM et al. PLoS Biol 2013 Jul;11(7):e1001597

PMID:7900424 - Assessment of pheromone production and response in fission yeast by a halo test of induced sporulation.

Egel R et al. Yeast 1994 Oct;10(10):1347-54

PMID:7975894 - Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Aono T et al. Yeast 1994 Jun;10(6):757-70

PMID:8264618 - Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

Xu HP et al. Mol Cell Biol 1994 Jan;14(1):50-8

PMID:8314086 - The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner.

Imai Y et al. Genes Dev 1994 Feb 01;8(3):328-38

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:8534915 - Schizosaccharomyces pombe zfs1+ encoding a zinc-finger protein functions in the mating pheromone recognition pathway.

Kanoh J et al. Mol Biol Cell 1995 Sep;6(9):1185-95

PMID:8846783 - Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.

Ottilie S et al. EMBO J 1995 Dec 01;14(23):5908-19

PMID:10593886 - Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5.

Yang P et al. J Biol Chem 1999 Dec 17;274(51):36052-7

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:9660817 - Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast.

Yang P et al. J Biol Chem 1998 Jul 17;273(29):18481-9