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protein coding gene - mdm10 (SPAC17H9.17c) - ERMES and SAM complex subunit Mdm10

Gene summary

Standard name
mdm10
Systematic ID
SPAC17H9.17c
Product
ERMES and SAM complex subunit Mdm10
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13814
ORFeome ID
44/44A08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2032009..2033322 reverse strand

Annotation

GO biological process

GO:7770063 - beta barrel protein insertion into mitochondrial outer membrane

References:

GO:0120010 - intermembrane phospholipid transfer

References:

GO cellular component

GO:0032865 - ERMES complex

References:

GO:0005739 - mitochondrion

References:

GO:0001401 - SAM complex

References:

GO molecular function

GO:0140474 - mitochondrion-endoplasmic reticulum membrane tether activity

References:

GO:0120014 - phospholipid transfer activity

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000021 - spheroid vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12519MDM10Mdm10Pfam
PTHR28035Mdm10PANTHER
MF_03102Mdm10Mdm10HAMAP

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:9024686 - Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast.
Berger KH et al. J Cell Biol 1997 Feb 10;136(3):545-53
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31