protein coding gene - hhf1 (SPAC1834.03c) - histone H4 h4.1

Gene summary

Standard name

hhf1

Systematic ID

SPAC1834.03c

Product

histone H4 h4.1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

h4.1

UniProt ID

P09322

ORFeome ID

01/01F02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4698773..4699599 reverse strand

Annotation

Protein features

Orthologs

• H4C16 (HGNC:20510) Homo sapiens
• H4C1 (HGNC:4781) Homo sapiens
• H4C4 (HGNC:4782) Homo sapiens
• H4C6 (HGNC:4783) Homo sapiens
• H4C12 (HGNC:4784) Homo sapiens
• H4C11 (HGNC:4785) Homo sapiens
• H4C3 (HGNC:4787) Homo sapiens
• H4C8 (HGNC:4788) Homo sapiens
• H4C2 (HGNC:4789) Homo sapiens
• H4C5 (HGNC:4790) Homo sapiens
• H4C13 (HGNC:4791) Homo sapiens
• H4C7 (HGNC:4792) Homo sapiens
• H4C9 (HGNC:4793) Homo sapiens
• H4C14 (HGNC:4794) Homo sapiens
• hhf3 (SJAG_00303) Schizosaccharomyces japonicus
• hhf1 (SJAG_00336) Schizosaccharomyces japonicus
• hhf2 (SJAG_03542) Schizosaccharomyces japonicus
• HHF1 (YBR009C) Saccharomyces cerevisiae
• HHF2 (YNL030W) Saccharomyces cerevisiae

References / Literature

PMID:30992049 - The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning.

Noguchi C et al. Epigenetics Chromatin 2019 Apr 16;12(1):24

PMID:22771823 - Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

Tong K et al. Eukaryot Cell 2012 Sep;11(9):1095-103

PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.

Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14

PMID:27890612 - In vitro reconstitution and biochemical analyses of the Schizosaccharomyces pombe nucleosome.

Koyama M et al. Biochem Biophys Res Commun 2017 Jan 22;482(4):896-901

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.

PMID:17677001 - Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4.

Castillo AG et al. PLoS Genet 2007 Jul;3(7):e121

PMID:26343758 - Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp.

An S et al. J Mol Biol 2015 Oct 09;427(20):3230-3240

PMID:34580178 - ATAD2 controls chromatin-bound HIRA turnover.

Wang T et al. Life Sci Alliance 2021 Dec;4(12)

PMID:31294478 - Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription.

Rivosecchi J et al. EMBO J 2019 Aug 15;38(16):e101955

PMID:22150589 - Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA.

Qiu Y et al. Biochem J 2012 Mar 15;442(3):527-38

PMID:16540522 - Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.

Nishijima H et al. Mol Biol Cell 2006 Jun;17(6):2524-36

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

GO_REF:0000002 - Comments

PMID:20403971 - Proteomic and functional analysis of the noncanonical poly(A) polymerase Cid14.

Keller C et al. RNA 2010 Jun;16(6):1124-9

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:17190600 - Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

Botuyan MV et al. Cell 2006 Dec 29;127(7):1361-73

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:25619998 - The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD.

Magin RS et al. Structure 2015 Feb 03;23(2):332-41

PMID:26275423 - Inner Kinetochore Protein Interactions with Regional Centromeres of Fission Yeast.

Thakur J et al. Genetics 2015 Oct;201(2):543-61

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

GO_REF:0000051 - S. pombe keyword mapping

PMID:24478943 - Pcf1, a large subunit of CAF-1, required for maintenance of checkpoint kinase Cds1 activity.

Kunoh T et al. Springerplus 2014;3:30

PMID:31371524 - Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.

Korntner-Vetter M et al. Life Sci Alliance 2019 Aug;2(4)

PMID:33670267 - The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.

Dong W et al. Int J Mol Sci 2021 Feb 11;22(4)

PMID:17114925 - A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.

Hong EJ et al. RNA Biol 2005;2(3):106-11

PMID:26401015 - Nucleosome competition reveals processive acetylation by the SAGA HAT module.

Ringel AE et al. Proc Natl Acad Sci U S A 2015 Oct 06;112(40):E5461-70

PMID:12535531 - A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast.

Chen ES et al. Mol Cell 2003 Jan;11(1):175-87

PMID:18826944 - Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage.

Greeson NT et al. J Biol Chem 2008 Nov 28;283(48):33168-74

PMID:21211723 - Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci.

Yamane K et al. Mol Cell 2011 Jan 07;41(1):56-66

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18579787 - The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module.

Stuwe T et al. Proc Natl Acad Sci U S A 2008 Jul 01;105(26):8884-9

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:27901072 - Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription.

Takayama Y et al. Sci Rep 2016 Nov 30;6:38111

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:20230746 - Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.

Takayama Y et al. Dev Cell 2010 Mar 16;18(3):385-96

PMID:39094570 - A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.

Yu J et al. Cell 2024 Sep 05;187(18):5010-5028.e24

PMID:17452352 - Differential regulation of repeated histone genes during the fission yeast cell cycle.

Takayama Y et al. Nucleic Acids Res 2007;35(10):3223-37

PMID:25298518 - Ectopic centromere nucleation by CENP--a in fission yeast.

Gonzalez M et al. Genetics 2014 Dec;198(4):1433-46

PMID:19250904 - Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein.

Wang Y et al. Mol Cell 2009 Feb 27;33(4):428-37

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:38376141 - Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe .

Ouasti F et al. Elife 2024 Feb 20;12

PMID:39878217 - The ortholog of human DNAJC9 promotes histone H3-H4 degradation and is counteracted by Asf1 in fission yeast.

Ding Y et al. Nucleic Acids Res 2025 Jan 24;53(3)

PMID:15550243 - Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.

Sanders SL et al. Cell 2004 Nov 24;119(5):603-14

PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.

Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:29804820 - Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A Cnp1 -Specific Assembly Factor through Eic1 Interaction.

An S et al. Structure 2018 Jul 03;26(7):960-971.e4

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30503616 - Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle.

Shukla M et al. Curr Biol 2018 Dec 17;28(24):3924-3936.e4

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41