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protein coding gene - klp3 (SPAC1834.07) - kinesin-like protein Klp3

Gene summary

Standard name
klp3
Systematic ID
SPAC1834.07
Product
kinesin-like protein Klp3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
krp1
UniProt ID
Q9US60
ORFeome ID
46/46D06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4706778..4709252 forward strand

Annotation

GO biological process

GO:0030705 - cytoskeleton-dependent intracellular transport

References:

GO:0007163 - establishment or maintenance of cell polarity

References:

GO:0007018 - microtubule-based movement

References:

GO cellular component

GO:0005938 - cell cortex

References:

GO:0005881 - cytoplasmic microtubule

References:

GO:0005871 - kinesin complex

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GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

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GO:0008017 - microtubule binding

References:

GO:0008574 - plus-end-directed microtubule motor activity

References:

GO:0005515 - protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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Multi-locus phenotype

FYPO:0002058 - viable cell population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0007057 - abnormal recycling endosome to Golgi transport

References:

Genotypes:

FYPO:0000117 - abnormal septum assembly

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Genotypes:

FYPO:0000134 - branched, elongated, multiseptate cell

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

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Genotypes:

FYPO:0000426 - normal endocytosis

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Genotypes:

FYPO:0007915 - normal endoplasmic reticulum localization

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0007912 - normal mitochondrial distribution

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Genotypes:

FYPO:0006259 - normal mitotic spindle length during metaphase

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Genotypes:

FYPO:0005342 - normal rate of mitotic spindle elongation during anaphase B

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Genotypes:

FYPO:0002716 - normal vacuole fusion during vegetative growth

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00225KinesinKinesin_motor_domPFAM
cd01369KISc_KHC_KIF5CDD
PS00411KINESIN_MOTOR_1Kinesin_motor_CSPROSITE_PATTERNS
PS50067KINESIN_MOTOR_2Kinesin_motor_domPROSITE_PROFILES
SM00129kinesin_4Kinesin_motor_domSMART
PR00380KINESINHEAVYKinesin_motor_domPRINTS
G3DSA:3.40.850.10:FF:000031FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.850.10Kinesin motor domainKinesin_motor_dom_sfGENE3D
PTHR47969CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATEDKinesin-like_famPANTHER

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:19686686 - Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.
Fu C et al. Dev Cell 2009 Aug;17(2):257-67
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:15850809 - ATP-binding motifs play key roles in Krp1p, kinesin-related protein 1, function for bi-polar growth control in fission yeast.
Rhee DK et al. Biochem Biophys Res Commun 2005 Jun 03;331(2):658-68
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
GO_REF:0000002 - Comments
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:11018050 - Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast.
Browning H et al. J Cell Biol 2000 Oct 02;151(1):15-28
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:32723864 - Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.
Zheng F et al. J Biol Chem 2020 Sep 18;295(38):13287-13298
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:12132578 - Cloning and characterization of the kinesin-related protein, Krp1p, in Schizosaccharomyces pombe.
Jeong JW et al. Mol Cells 2002 Jun 30;13(3):389-98
PMID:10641037 - A fission yeast kinesin affects Golgi membrane recycling.
Brazer SC et al. Yeast 2000 Jan 30;16(2):149-66
PMID:24239120 - Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation.
Syrovatkina V et al. Curr Biol 2013 Dec 02;23(23):2423-9
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704