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protein coding gene - ldh1 (SPAC186.08c) - L-lactate dehydrogenase Ldh1

Gene summary

Standard name
ldh1
Systematic ID
SPAC186.08c
Product
L-lactate dehydrogenase Ldh1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7P7
ORFeome ID
17/17G04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 5548884..5550012 reverse strand

Annotation

Disease association

MONDO:0013587 - glycogen storage disease due to lactate dehydrogenase H-subunit deficiency

References:

MONDO:0013047 - glycogen storage disease due to lactate dehydrogenase M-subunit deficiency

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GO biological process

GO:0006089 - lactate metabolic process

References:

GO:0051596 - methylglyoxal catabolic process

References:

GO:0042867 - pyruvate catabolic process

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0004459 - L-lactate dehydrogenase (NAD+) activity

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00056Ldh_1_NLactate/malate_DH_NPfam
PF02866Ldh_1_CLactate/malate_DH_CPfam
cd05292LDH_2CDD
PS00064L_LDHL-lactate_DH_ASPROSITE patterns
PR00086LLDHDRGNASEL-lactate/malate_DHPRINTS
G3DSA:3.40.50.720:FF:000018CATH-FunFam
G3DSA:3.40.50.720CATH-Gene3D
G3DSA:3.90.110.10Lactate_DH/Glyco_Ohase_4_CCATH-Gene3D
SSF51735NAD(P)-bd_dom_sfSUPERFAMILY
SSF56327Lactate_DH/Glyco_Ohase_4_CSUPERFAMILY
PTHR43128PANTHER
PIRSF000102Lac_mal_DHL-lactate/malate_DHPIRSF
NF000824PRK00066.1NCBIFAM
TIGR01771L-LDH-NADL-lactate_DHNCBIFAM
MF_00488Lactate_dehydrogL-lactate_DHHAMAP

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29188185 - Metabolic engineering of Schizosaccharomyces pombe via CRISPR-Cas9 genome editing for lactic acid production from glucose and cellobiose.
Ozaki A et al. Metab Eng Commun 2017 Dec;5:60-67
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .
Wiley DJ et al. Front Physiol 2020;11:427
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105