protein coding gene - ldh1 (SPAC186.08c) - L-lactate dehydrogenase Ldh1

Gene summary

Standard name: ldh1
Systematic ID: SPAC186.08c
Product: L-lactate dehydrogenase Ldh1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9P7P7
ORFeome ID: 17/17G04
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 5548884..5550012 reverse strand

Annotation

Disease association

MONDO:0013587 - glycogen storage disease due to lactate dehydrogenase H-subunit deficiency

References:

PB_REF:0000006

MONDO:0013047 - glycogen storage disease due to lactate dehydrogenase M-subunit deficiency

References:

PB_REF:0000006

GO biological process

GO:0006089 - lactate metabolic process

References:

GO_REF:0000033

GO:0051596 - methylglyoxal catabolic process

References:

GO_REF:0000111

GO:0042867 - pyruvate catabolic process

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0004459 - L-lactate dehydrogenase (NAD+) activity

References:

GO_REF:0000033

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000011 - RNA level increased

References:

PMID:16537923

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002693 - resistance to diamide

References:

PMID:37787768

Genotypes:

ldh1delta

FYPO:0009035 - resistance to formamide

References:

PMID:37787768

Genotypes:

ldh1delta

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

ldh1delta

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30647105

Genotypes:

ldh1delta

FYPO:0000096 - sensitive to cadmium

References:

PMID:37787768

Genotypes:

ldh1delta

FYPO:0001719 - sensitive to lithium

References:

PMID:37787768

Genotypes:

ldh1delta

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

ldh1delta

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

ldh1delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

ldh1delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

ldh1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

ID	Name	InterPro name	DB name
PF00056	Ldh_1_N	Lactate/malate_DH_N	PFAM
PF02866	Ldh_1_C	Lactate/malate_DH_C	PFAM
cd05292	LDH_2		CDD
PS00064	L_LDH	L-lactate_DH_AS	PROSITE_PATTERNS
PR00086	LLDHDRGNASE	L-lactate/malate_DH	PRINTS
G3DSA:3.40.50.720:FF:000018			FUNFAM
SSF56327	LDH C-terminal domain-like	Lactate_DH/Glyco_Ohase_4_C	SUPERFAMILY
SSF51735	NAD(P)-binding Rossmann-fold domains	NAD(P)-bd_dom_sf	SUPERFAMILY
G3DSA:3.90.110.10		Lactate_DH/Glyco_Ohase_4_C	GENE3D
G3DSA:3.40.50.720			GENE3D
PTHR43128	L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))		PANTHER
PIRSF000102	Lac_mal_DH	L-lactate/malate_DH	PIRSF
MF_00488	Lactate_dehydrog	L-lactate_DH	HAMAP
NF000824	PRK00066.1		NCBIFAM
TIGR01771	L-LDH-NAD	L-lactate_DH	NCBIFAM

Orthologs

LDHAL6A (HGNC:28335) Homo sapiens
LDHA (HGNC:6535) Homo sapiens
LDHB (HGNC:6541) Homo sapiens

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .: Wiley DJ et al. Front Physiol 2020;11:427
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:29188185 - Metabolic engineering of Schizosaccharomyces pombe via CRISPR-Cas9 genome editing for lactic acid production from glucose and cellobiose.: Ozaki A et al. Metab Eng Commun 2017 Dec;5:60-67
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.: Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83