PomBase home

protein coding gene - pdc102 (SPAC186.09) - pyruvate decarboxylase

Gene summary

Standard name
pdc102
Systematic ID
SPAC186.09
Product
pyruvate decarboxylase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7P6
ORFeome ID
45/45F03
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 5552811..5554529 forward strand

Annotation

GO biological process

GO:0019660 - pyruvate fermentation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0000287 - magnesium ion binding

References:

GO:0004737 - pyruvate decarboxylase activity

References:

GO:0030976 - thiamine pyrophosphate binding

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000013 - RNA level unchanged

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001310 - normal viability in stationary phase

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF02776TPP_enzyme_NThiamin_PyroP_enz_TPP-bd_domPFAM
PF00205TPP_enzyme_MThiamin_PyroP_enz_cen_domPFAM
PF02775TPP_enzyme_CTPP_enzyme_TPP-bdPFAM
cd02005TPP_PDC_IPDCTPP_PDC_IPDCCDD
cd07038TPP_PYR_PDC_IPDC_likeTPP_PYR_PDC_IPDC-likeCDD
PS00187TPP_ENZYMESTPP-bd_CSPROSITE_PATTERNS
G3DSA:3.40.50.970:FF:000024FUNFAM
G3DSA:3.40.50.1220:FF:000009FUNFAM
G3DSA:3.40.50.970:FF:000019FUNFAM
SSF52467DHS-like NAD/FAD-binding domainDHS-like_NAD/FAD-binding_domSUPERFAMILY
SSF52518Thiamin diphosphate-binding fold (THDP-binding)THDP-bindingSUPERFAMILY
G3DSA:3.40.50.1220GENE3D
G3DSA:3.40.50.970GENE3D
PTHR43452PYRUVATE DECARBOXYLASEPDC/IPDC-likePANTHER
PIRSF036565Pyruvt_ip_decrbPDC/IPDC-likePIRSF

References / Literature

GO_REF:0000002 - Comments
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.
Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:25102102 - A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast.
Kim JY et al. Aging (Albany NY) 2014 Jul;6(7):587-601
GO_REF:0000033 - Annotation inferences using phylogenetic trees