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protein coding gene - gpi18 (SPAC18B11.05) - pig-V, dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase

Gene summary

Standard name
gpi18
Systematic ID
SPAC18B11.05
Product
pig-V, dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09712
ORFeome ID
20/20E04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 308138..309919 reverse strand

Annotation

Disease association

MONDO:0009398 - hyperphosphatasia with intellectual disability syndrome 1

References:

MONDO:0001071 - intellectual disability

References:

GO biological process

GO:0006506 - GPI anchor biosynthetic process

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO:0120097 - glycosylphosphatidylinositol-mannosyltransferase II complex

References:

GO molecular function

GO:0120563 - dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0002482 - inviable spheroid vegetative cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF04188Mannosyl_trans2PIG-V/Gpi18Pfam
PTHR12468PIG-V/Gpi18PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PB_REF:0000003 - Disease Association Curation
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:15623507 - PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol.
Kang JY et al. J Biol Chem 2005 Mar 11;280(10):9489-97
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6