protein coding gene - tup11 (SPAC18B11.10) - transcriptional corepressor Tup11

Gene summary

Standard name

tup11

Systematic ID

SPAC18B11.10

Product

transcriptional corepressor Tup11

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09715

ORFeome ID

27/27G06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 299278..301796 reverse strand

Annotation

Protein features

Orthologs

• tup11 (SJAG_00290) Schizosaccharomyces japonicus
• TUP1 (YCR084C) Saccharomyces cerevisiae

References / Literature

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:17101775 - Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes.

Fagerström-Billai F et al. Mol Cell Biol 2007 Feb;27(3):1069-82

PMID:12221110 - Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.

Greenall A et al. Mol Biol Cell 2002 Sep;13(9):2977-89

PMID:11238405 - Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Janoo RT et al. Genetics 2001 Mar;157(3):1205-15

PMID:17724773 - Expression of Candida albicans Sfu1 in fission yeast complements the loss of the iron-regulatory transcription factor Fep1 and requires Tup co-repressors.

Pelletier B et al. Yeast 2007 Oct;24(10):883-900

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:10567571 - Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog.

Mukai Y et al. Mol Cell Biol 1999 Dec;19(12):8461-8

PMID:15632072 - Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast.

Fagerström-Billai F et al. Mol Cell Biol 2005 Jan;25(2):716-27

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhang L et al. PLoS One 2013;8(7):e68738

PMID:25535331 - Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor.

Asada R et al. Mol Cell Biol 2015 Mar;35(5):847-55

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:30922219 - A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe.

Vassiliadis D et al. BMC Genomics 2019 Mar 29;20(1):251

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:11956219 - Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe.

Pelletier B et al. J Biol Chem 2002 Jun 21;277(25):22950-8

PMID:15866870 - Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe.

Pelletier B et al. J Biol Chem 2005 Jul 01;280(26):25146-61

PMID:18820678 - Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs.

Hirota K et al. Nature 2008 Nov 06;456(7218):130-4

PMID:18622392 - Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.

Monahan BJ et al. Nat Struct Mol Biol 2008 Aug;15(8):873-80

PMID:20200159 - The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.

Kang WH et al. J Biol Chem 2010 Apr 30;285(18):13797-806

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:34349749 - Exomer Is Part of a Hub Where Polarized Secretion and Ionic Stress Connect.

Moro S et al. Front Microbiol 2021;12:708354

PMID:14668334 - The Schizosaccharomyces pombe corepressor Tup11 interacts with the iron-responsive transcription factor Fep1.

Znaidi S et al. J Biol Chem 2004 Mar 05;279(10):9462-74

PMID:36358992 - Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription.

Asada R et al. Biomolecules 2022 Nov 05;12(11)

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:20544037 - WD40 domain divergence is important for functional differences between the fission yeast Tup11 and Tup12 co-repressor proteins.

Ferreira ME et al. PLoS One 2010 Jun 08;5(6):e11009

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:29967244 - Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression.

Umeda M et al. Mol Cell Biol 2018 Sep 15;38(18)

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:12637515 - Physical and functional interaction of the yeast corepressor Tup1 with mRNA 5'-triphosphatase.

Mukai Y et al. J Biol Chem 2003 May 23;278(21):18895-901

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:20396879 - The gld1+ gene encoding glycerol dehydrogenase is required for glycerol metabolism in Schizosaccharomyces pombe.

Matsuzawa T et al. Appl Microbiol Biotechnol 2010 Jun;87(2):715-27

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28934464 - Recruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors.

Asada R et al. Nucleic Acids Res 2017 Sep 19;45(16):9361-9371

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:21421748 - Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1.

Jbel M et al. Eukaryot Cell 2011 May;10(5):629-45

PMID:22226946 - The Ubiquitin ligase Ubr11 is essential for oligopeptide utilization in the fission yeast Schizosaccharomyces pombe.

Kitamura K et al. Eukaryot Cell 2012 Mar;11(3):302-10