PomBase home

protein coding gene - lem2 (SPAC18G6.10) - LEM domain nuclear inner membrane protein Heh1/Lem2

Gene summary

Standard name
lem2
Systematic ID
SPAC18G6.10
Product
LEM domain nuclear inner membrane protein Heh1/Lem2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
heh1
UniProt ID
Q10109
ORFeome ID
46/46D11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2234278..2236773 forward strand

Annotation

Disease association

MONDO:0008925 - cataract 46 juvenile-onset

References:

MONDO:0859147 - Marbach-Rustad progeroid syndrome

References:

GO biological process

GO:0140698 - attachment of telomeric heterochromatin to nuclear envelope

References:

GO:0072766 - centromere clustering at the mitotic interphase nuclear envelope

References:

GO:0070828 - heterochromatin organization

References:

GO:0007084 - mitotic nuclear membrane reassembly

References:

GO:0071765 - nuclear inner membrane organization

References:

GO:0071763 - nuclear membrane organization

References:

GO:0140464 - subnuclear spatial organization of silent mating-type cassette heterochromatin

References:

GO cellular component

GO:0061638 - CENP-A containing chromatin

References:

GO:0034506 - chromosome, centromeric core domain

References:

GO:0099115 - chromosome, subtelomeric region

References:

GO:0140599 - mitotic nuclear bridge midzone membrane domain

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0005635 - nuclear envelope

References:

GO:0005637 - nuclear inner membrane

References:

GO:0031965 - nuclear membrane

References:

GO:0034399 - nuclear periphery

References:

GO:0005721 - pericentric heterochromatin

References:

GO:0033553 - rDNA heterochromatin

References:

GO molecular function

GO:0140449 - centromere-nuclear envelope anchor activity

References:

GO:0019237 - centromeric DNA binding

References:

GO:0003682 - chromatin binding

References:

GO:0003690 - double-stranded DNA binding

References:

GO:0062239 - heterochromatin-nuclear membrane anchor activity

References:

GO:0005515 - protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01149 - sumoylated lysine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000769 - abnormal nuclear envelope morphology during vegetative growth

References:

Genotypes:

FYPO:0005554 - abolished histone H3-K9 dimethylation at centromere inner repeat during vegetative growth

References:

Genotypes:

FYPO:0002568 - abolished protein localization to nuclear periphery

References:

Genotypes:

FYPO:0000770 - branched nuclear inner membrane

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0006881 - decreased cellular phytoceramide level

References:

Genotypes:

FYPO:0006800 - decreased centromere clustering at nuclear periphery during mitotic interphase

References:

Genotypes:

FYPO:0003411 - decreased chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0000888 - decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0000940 - decreased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0002339 - decreased protein localization to nuclear periphery

References:

Genotypes:

FYPO:0006882 - imperforate nuclear envelope

References:

Genotypes:

FYPO:0000887 - increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0005371 - increased linear minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0006926 - increased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0005917 - increased subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0002430 - inviable after spore germination, multiple cell divisions

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003166 - monoseptate vegetative cell with binucleate and anucleate compartments

References:

Genotypes:

FYPO:0008178 - normal centromeric inner repeat transcript level

References:

Genotypes:

FYPO:0002891 - normal chromatin organization during vegetative growth

References:

Genotypes:

FYPO:0002360 - normal chromatin silencing at centromere

References:

Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

References:

Genotypes:

FYPO:0001839 - normal minichromosome loss

References:

Genotypes:

FYPO:0003751 - normal nuclear envelope morphology

References:

Genotypes:

FYPO:0001380 - normal nuclear morphology during vegetative growth

References:

Genotypes:

FYPO:0001221 - normal nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0005602 - normal subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0002085 - normal vegetative cell growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000772 - perforated nuclear envelope

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein features

PBO:0111859 - LEM domain

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000805 - abnormal endoplasmic reticulum organization

References:

Genotypes:

FYPO:0000051 - abnormal meiosis

References:

Genotypes:

FYPO:0000173 - abnormal mitotic cell cycle DNA replication checkpoint

References:

Genotypes:

FYPO:0010058 - abnormal nuclear envelope morphology during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0000769 - abnormal nuclear envelope morphology during vegetative growth

References:

Genotypes:

FYPO:0001515 - abnormal telomere tethering at nuclear periphery during vegetative growth

References:

Genotypes:

FYPO:0004790 - abnormal telomere-nuclear envelope distance during vegetative growth

References:

Genotypes:

FYPO:0006106 - abolished chromatin binding at centromere central core

References:

Genotypes:

FYPO:0000659 - abolished DNA binding

References:

Genotypes:

FYPO:0010034 - abolished nuclear pore clustering during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0000941 - abolished protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0004886 - abolished protein localization to nuclear envelope during vegetative growth

References:

Genotypes:

FYPO:0005934 - abolished protein sumoylation during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0000278 - decreased cell population growth following spore germination

References:

Genotypes:

FYPO:0006800 - decreased centromere clustering at nuclear periphery during mitotic interphase

References:

Genotypes:

FYPO:0002577 - decreased chromatin binding

References:

Genotypes:

FYPO:0003411 - decreased chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0004604 - decreased chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0000877 - decreased histone H3-K9 dimethylation at centromere during vegetative growth

References:

Genotypes:

FYPO:0000878 - decreased histone H3-K9 dimethylation at centromere inner repeat during vegetative growth

References:

Genotypes:

FYPO:0000888 - decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0008087 - decreased nucleophagy during nitrogen starvation

References:

Genotypes:

FYPO:0006927 - decreased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0000835 - decreased protein level

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002909 - decreased protein localization to chromatin during vegetative growth

References:

Genotypes:

FYPO:0002339 - decreased protein localization to nuclear periphery

References:

Genotypes:

FYPO:0001514 - decreased protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

References:

Genotypes:

FYPO:0002387 - decreased protein localization to subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0002098 - decreased protein phosphorylation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0010084 - decreased protein targeting to vacuole during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001556 - excess nuclear envelope present

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0002980 - increased chromatin binding

References:

Genotypes:

FYPO:0005371 - increased linear minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0004342 - increased LTR-derived RNA level

References:

Genotypes:

FYPO:0006926 - increased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0001908 - increased pre-mRNA level

References:

Genotypes:

FYPO:0003009 - increased protein localization to centromere outer repeat

References:

Genotypes:

FYPO:0003011 - increased protein localization to chromatin during vegetative growth

References:

Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0003010 - increased protein localization to subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0005917 - increased subtelomeric heterochromatin RNA level

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0003166 - monoseptate vegetative cell with binucleate and anucleate compartments

References:

Genotypes:

FYPO:0001870 - normal centromere clustering at nuclear periphery during vegetative growth

References:

Genotypes:

FYPO:0008178 - normal centromeric inner repeat transcript level

References:

Genotypes:

FYPO:0003086 - normal chromatin binding

References:

Genotypes:

FYPO:0004879 - normal chromatin binding at centromere central core

References:

Genotypes:

FYPO:0002360 - normal chromatin silencing at centromere

References:

Genotypes:

FYPO:0006995 - normal chromatin silencing at centromere inner repeat

References:

Genotypes:

FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

References:

Genotypes:

FYPO:0003555 - normal chromatin silencing at subtelomere

References:

Genotypes:

FYPO:0000655 - normal DNA binding

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0000964 - normal growth on thiabendazole

References:

Genotypes:

FYPO:0006429 - normal histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0001513 - normal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0001380 - normal nuclear morphology during vegetative growth

References:

Genotypes:

FYPO:0000771 - normal nuclear pore localization

References:

Genotypes:

FYPO:0010088 - normal nucleophagy during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0001221 - normal nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0003627 - normal protein localization

References:

Genotypes:

FYPO:0004314 - normal protein localization to CENP-A containing chromatin

References:

Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

References:

Genotypes:

FYPO:0005612 - normal protein localization to nuclear envelope

References:

Genotypes:

FYPO:0000838 - normal protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0002899 - normal protein phosphorylation during cellular response to DNA damage

References:

Genotypes:

FYPO:0002099 - normal protein phosphorylation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0007448 - normal reticulophagy during nitrogen starvation

References:

Genotypes:

FYPO:0004924 - normal telomere tethering at nuclear periphery during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0006928 - nuclear membrane blebbing

References:

Genotypes:

FYPO:0000772 - perforated nuclear envelope

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0001450 - resistance to cold

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005969 - resistance to magnesium chloride

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009089 - resistance to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

References:

Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF09402MSCMan1/Src1-like_CPfam
PF12949HeHHeH/LEM_domainPfam
cd12935LEM_likeCDD
G3DSA:1.10.10.1180MAN1_winged_helix_domCATH-Gene3D
PTHR47808Heh2/Src1PANTHER
Transmembrane alpha helixDeepTMHMM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:29722648 - Distinct 'safe zones' at the nuclear envelope ensure robust replication of heterochromatic chromosome regions.
Ebrahimi H et al. Elife 2018 May 03;7
PMID:32502403 - Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast.
Expósito-Serrano M et al. Curr Biol 2020 Aug 17;30(16):3212-3222.e2
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27889481 - Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.
Fernández-Álvarez A et al. Dev Cell 2016 Dec 05;39(5):544-559
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22895252 - A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA.
Kawakami K et al. Genes Dev 2012 Aug 15;26(16):1811-24
PMID:26746798 - Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeast.
Xu YJ Cell Signal 2016 Apr;28(4):235-45
PMID:22540024 - Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina.
Gonzalez Y et al. Nucleus 2012;3(1):60-76
PMID:35354597 - Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe .
Varberg JM et al. Life Sci Alliance 2022 Jul;5(7)
PMID:27172183 - Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.
Larson A et al. G3 (Bethesda) 2016 Jun 01;6(6):1513-23
PMID:37783794 - An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity.
Ader NR et al. Nat Cell Biol 2023 Oct;25(10):1465-1477
PMID:30975915 - The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells.
Kinugasa Y et al. J Cell Sci 2019 May 15;132(10)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.
Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837
PMID:34133218 - Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
Bestul AJ et al. Mol Biol Cell 2021 Aug 01;32(16):1487-1500
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30462301 - Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.
Hu C et al. Nucleic Acids Res 2019 Feb 20;47(3):1573-1584
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:37078207 - Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation.
Hirano Y et al. J Cell Sci 2023 May 15;136(10)
PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Mojardín L et al. Cell Cycle 2015;14(2):206-18
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:26744419 - Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
Barrales RR et al. Genes Dev 2016 Jan 15;30(2):133-48
PMID:31483748 - Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.
Zhurinsky J et al. Mol Biol Cell 2019 Oct 01;30(21):2695-2708
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.
Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
PMID:27334362 - Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions.
Tange Y et al. Genes Cells 2016 Aug;21(8):812-32
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20404563 - High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.
Rumpf C et al. Cell Cycle 2010 May;9(9):1802-8
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.
Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:29292846 - Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast.
Hirano Y et al. Genes Cells 2018 Mar;23(3):122-135
PMID:32824370 - Nuclear Envelope Proteins Modulating the Heterochromatin Formation and Functions in Fission Yeast.
Hirano Y et al. Cells 2020 Aug 16;9(8)
PMID:39892963 - The losses of Lem2 and Bqt4 exhibit similar impacts on intracellular movement dynamics in fission yeast.
Wang K et al. Biochem Biophys Res Commun 2025 Feb 16;749:151326
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:31015410 - Nuclear membrane protein Lem2 regulates nuclear size through membrane flow.
Kume K et al. Nat Commun 2019 Apr 23;10(1):1871
PMID:21880100 - Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres.
Hiraoka Y et al. Genes Cells 2011 Oct;16(10):1000-11
PMID:32817556 - Integrity of a heterochromatic domain ensured by its boundary elements.
Charlton SJ et al. Proc Natl Acad Sci U S A 2020 Sep 01;117(35):21504-21511
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:30503780 - The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope.
Hu C et al. Structure 2019 Feb 05;27(2):335-343.e3
PMID:28242692 - LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.
Gu M et al. Proc Natl Acad Sci U S A 2017 Mar 14;114(11):E2166-E2175
PMID:27451393 - Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing.
Banday S et al. J Biol Chem 2016 Sep 16;291(38):20021-9
PMID:36799444 - Inner nuclear membrane proteins Lem2 and Bqt4 interact with different lipid synthesis enzymes in fission yeast.
Hirano Y et al. J Biochem 2023 Jun 30;174(1):33-46
PMID:41917004 - Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast.
Ma ZH et al. Nat Commun 2026 Mar 31;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:28678660 - The functionally elusive RabI chromosome configuration directly regulates nuclear membrane remodeling at mitotic onset.
Fernández-Álvarez A et al. Cell Cycle 2017 Aug 03;16(15):1392-1396
PMID:32848252 - Closed mitosis requires local disassembly of the nuclear envelope.
Dey G et al. Nature 2020 Sep;585(7823):119-123
PMID:18692466 - A network of nuclear envelope membrane proteins linking centromeres to microtubules.
King MC et al. Cell 2008 Aug 08;134(3):427-38
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80