protein coding gene - imp4 (SPAC19A8.07c) - U3 snoRNP-associated protein Imp4

Gene summary

Standard name: imp4
Systematic ID: SPAC19A8.07c
Product: U3 snoRNP-associated protein Imp4
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O13823
ORFeome ID: 11/11G02
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 2474657..2475765 forward strand

Annotation

GO biological process

GO:0042274 - ribosomal small subunit biogenesis

References:

GO_REF:0000024

GO:0006364 - rRNA processing

References:

GO_REF:0000033

GO cellular component

GO:0034457 - Mpp10 complex

References:

GO_REF:0000033

GO:0005730 - nucleolus

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO:0032040 - small-subunit processome

References:

GO_REF:0000033

GO molecular function

GO:0042134 - rRNA primary transcript binding

References:

GO_REF:0000002

GO:0030515 - snoRNA binding

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:39367033

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:23101633

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

imp4delta

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

PMID:23697806

Genotypes:

imp4delta

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

PMID:23697806

Genotypes:

imp4delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

imp4delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

imp4delta

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF04427	Brix	Brix	PFAM
PS50833	BRIX	Brix	PROSITE_PROFILES
SM00879	Brix_2	Brix	SMART
G3DSA:3.40.50.10480:FF:000001			FUNFAM
SSF52954	Class II aaRS ABD-related		SUPERFAMILY
G3DSA:3.40.50.10480			GENE3D
PTHR22734	U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4	IMP4/RPF1	PANTHER
Coil	Coil		COILS
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

Orthologs

IMP4 (HGNC:30856) Homo sapiens
imp4 (SJAG_03252) Schizosaccharomyces japonicus
IMP4 (YNL075W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.: Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.: Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.: Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:38051102 - Fission Yeast TORC1 Promotes Cell Proliferation through Sfp1, a Transcription Factor Involved in Ribosome Biogenesis.: Tai YT et al. Mol Cell Biol 2023 Dec 05;:1-18
GO_REF:0000002 - Comments
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.: Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183