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protein coding gene - ttc27 (SPAC19B12.01) - eEF2 folding chaperone Ttc27

Gene summary

Standard name
ttc27
Systematic ID
SPAC19B12.01
Product
eEF2 folding chaperone Ttc27
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC4F10.21, ceo5
UniProt ID
O36033
ORFeome ID
38/38D07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 4875387..4878120 forward strand

Annotation

GO biological process

GO:0051083 - 'de novo' cotranslational protein folding

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0044183 - protein folding chaperone

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Modification

MOD:01148 - ubiquitinylated lysine

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Protein features

PBO:0111755 - TPR repeat protein

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000029 - RNA level decreased during Core Environmental Stress Response

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000017 - elongated cell

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Genotypes:

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF13181TPR_8TPR_rptPfam
PS50005TPRTPR_rptPROSITE profiles
SM00028TPRTPR_rptSMART
G3DSA:1.25.40.10:FF:000884CATH-FunFam
G3DSA:1.25.40.10TPR-like_helical_dom_sfCATH-Gene3D
SSF48452TPR-like_helical_dom_sfSUPERFAMILY
PTHR16193TTC27/Emw1PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:37162093 - Genetic knockdown of genes that are obscure, conserved and essential using CRISPR interference methods in the fission yeast S. pombe.
Ishikawa K et al. J Cell Sci 2023 May 01;136(9)
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:41806041 - Emw1/TTC27 is a chaperone required for folding of the eukaryotic elongation factor 2.
Yang M et al. Cell Mol Life Sci 2026 Mar 10;
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36