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protein coding gene - gas1 (SPAC19B12.02c) - cell wall 1,3-beta-glucanosyltransferase Gas1

Gene summary

Standard name
gas1
Systematic ID
SPAC19B12.02c
Product
cell wall 1,3-beta-glucanosyltransferase Gas1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P378
ORFeome ID
45/45D12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4878579..4880740 reverse strand

Annotation

GO biological process

GO:0071970 - fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process

References:

GO:0031505 - fungal-type cell wall organization

References:

GO cellular component

GO:0032153 - cell division site

References:

GO:0009897 - external side of plasma membrane

References:

GO:0009277 - fungal-type cell wall

References:

GO:0035841 - new growing cell tip

References:

GO:0035840 - old growing cell tip

References:

GO molecular function

GO:0042124 - 1,3-beta-glucanosyltransferase activity

References:

Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00818 - glycosylphosphatidylinositolated residue

References:

MOD:00006 - N-glycosylated residue

References:

MOD:00171 - N-seryl-glycosylphosphatidylinositolethanolamine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0001235 - decreased extent of cell population growth

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000017 - RNA level fluctuates

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000164 - abnormal cell separation after cytokinesis

References:

Genotypes:

FYPO:0000182 - abnormal cell wall organization during vegetative growth

References:

Genotypes:

FYPO:0003440 - cell lysis during cytokinesis

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0005158 - decreased cell wall (1->6)-beta-D-glucan level

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001190 - sensitive to cell wall-degrading enzymes

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0000647 - vegetative cell lysis

References:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03198Glyco_hydro_72GlucanosyltransferasePFAM
PF07983X8X8PFAM
SM00768X8_clsX8SMART
G3DSA:3.20.20.80:FF:000038FUNFAM
SSF51445(Trans)glycosidasesGHSUPERFAMILY
G3DSA:3.20.20.80GlycosidasesGENE3D
G3DSA:1.20.58.1040GENE3D
PTHR314681,3-BETA-GLUCANOSYLTRANSFERASE GAS1GlucanosyltransferasePANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000007 - Prediction of GPI-anchored proteins with pointer neural networks
PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:17230583 - Mass spectrometric identification of covalently bound cell wall proteins from the fission yeast Schizosaccharomyces pombe.
de Groot PW et al. Yeast 2007 Apr;24(4):267-78
PMID:25847133 - RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast.
Nakazawa N et al. Genes Cells 2015 Jun;20(6):481-99
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:31601154 - gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe .
Imai Y et al. Biosci Biotechnol Biochem 2020 Feb;84(2):330-337
PMID:31615333 - Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.
Nakazawa N et al. Open Biol 2019 Oct 31;9(10):190125
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:33771877 - RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.
Rivosecchi J et al. Life Sci Alliance 2021 Jun;4(6)
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:38511077 - Generation and characterization of temperature-sensitive alleles of the glucanosyltransferase Gas1 in Schizosaccharomyces pombe.
Howard IV et al. MicroPubl Biol 2024;2024
PMID:21124977 - β(1,3)-glucanosyl-transferase activity is essential for cell wall integrity and viability of Schizosaccharomyces pombe.
de Medina-Redondo M et al. PLoS One 2010 Nov 18;5(11):e14046
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27974503 - Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast.
Hoya M et al. Genetics 2017 Feb;205(2):673-690
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;