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protein coding gene - cox1102 (SPAC19B12.13) - cytochrome c oxidase copper chaperone Cox1102/ mitochondrial ribosome assembly protein Rsm2202, fusion protein

Gene summary

Standard name
cox1102
Systematic ID
SPAC19B12.13
Product
cytochrome c oxidase copper chaperone Cox1102/ mitochondrial ribosome assembly protein Rsm2202, fusion protein
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
cox11, cox11-b, SPAPB8E5.01, cox11
UniProt ID
Q86ZU7
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4906978..4909314 forward strand

Annotation

Comment

PBO:0000877 - target of TIM23 translocase

Disease association

MONDO:0859520 - mitochondrial complex IV deficiency, nuclear type 23

References:

MONDO:0016387 - mitochondrial oxidative phosphorylation disorder

References:

GO biological process

GO:0033617 - mitochondrial respiratory chain complex IV assembly

References:

GO:0032543 - mitochondrial translation

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0016531 - copper chaperone activity

References:

GO:0005507 - copper ion binding

References:

GO:0008168 - methyltransferase activity

References:

Genome organisation

PBO:0000228 - domain combination not observed in other organisms

PBO:0000229 - tandem fusion protein

Modification

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0100011 - cleaved_peptide_region

SO:0001808 - mitochondrial_targeting_signal

References:

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF04442CtaG_Cox11Cyt_c_oxidase_assmbl_CtaGPfam
PF09243Rsm22Ribosomal_Rsm22-likePfam
G3DSA:2.60.370.10:FF:000001CATH-FunFam
G3DSA:2.60.370.10CtaG/Cox11_dom_sfCATH-Gene3D
SSF110111CtaG/Cox11_dom_sfSUPERFAMILY
PTHR21320PANTHER
NF003465PRK05089.1NCBIFAM
Transmembrane alpha helixDeepTMHMM
MF_00155CtaGCyt_c_oxidase_assmbl_CtaGHAMAP

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:38068960 - Novel COX11 Mutations Associated with Mitochondrial Disorder: Functional Characterization in Patient Fibroblasts and Saccharomyces cerevisiae .
Caron-Godon CA et al. Int J Mol Sci 2023 Nov 23;24(23)
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8