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protein coding gene - fin1 (SPAC19E9.02) - serine/threonine protein kinase, NIMA related Fin1

Gene summary

Standard name
fin1
Systematic ID
SPAC19E9.02
Product
serine/threonine protein kinase, NIMA related Fin1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13839
ORFeome ID
28/28H11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1354221..1357184 forward strand

Annotation

Comment

PBO:0024819 - promoter contains PCB

References:

Complementation

PBO:0016918 - does not functionally complement A. nidulans nimA

References:

Disease association

MONDO:0014256 - retinitis pigmentosa 67

References:

GO biological process

GO:0007059 - chromosome segregation

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GO:0031030 - negative regulation of septation initiation signaling

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GO:0006998 - nuclear envelope organization

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GO:0010971 - positive regulation of G2/M transition of mitotic cell cycle

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0072686 - mitotic spindle

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GO:0044732 - mitotic spindle pole body

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GO:0005635 - nuclear envelope

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GO:0005634 - nucleus

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GO molecular function

GO:0004674 - protein serine/threonine kinase activity

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GO:0004712 - protein serine/threonine/tyrosine kinase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

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Genotypes:

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

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Genotypes:

FYPO:0003738 - abnormal mitotic cell cycle arrest with condensed chromosomes

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Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

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Genotypes:

FYPO:0000338 - abnormal mitotic spindle

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Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

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Genotypes:

FYPO:0001489 - inviable vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000276 - monopolar mitotic spindle

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000405 - normal mitotic G2/M phase transition

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Genotypes:

FYPO:0001399 - normal mitotic spindle

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Genotypes:

FYPO:0002967 - normal protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0001124 - normal vegetative cell size

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Genotypes:

FYPO:0007566 - premature mitotic chromosome condensation

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Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0006821 - slow vegetative cell growth

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Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000021 - protein present

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PomGeneEx:0000017 - RNA level fluctuates

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PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000620 - abnormal cell cycle arrest in mitotic metaphase

References:

Genotypes:

FYPO:0003738 - abnormal mitotic cell cycle arrest with condensed chromosomes

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Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

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Genotypes:

FYPO:0000338 - abnormal mitotic spindle

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Genotypes:

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0004702 - cytoplasmic microtubules absent from cell

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0007574 - decreased duration of protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0003306 - decreased mitotic index

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Genotypes:

FYPO:0003737 - delayed onset of protein phosphorylation during mitotic G2 phase

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Genotypes:

FYPO:0004167 - increased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0009096 - increased cell population growth on xylose carbon source

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Genotypes:

FYPO:0007385 - increased duration of protein-protein interaction

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Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

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Genotypes:

FYPO:0002969 - increased protein localization to mitotic spindle pole body

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Genotypes:

FYPO:0000252 - increased spontaneous diploidization

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

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Genotypes:

FYPO:0000276 - monopolar mitotic spindle

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Genotypes:

FYPO:0005960 - multipolar mitotic spindle

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0003736 - normal mitotic index

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Genotypes:

FYPO:0001399 - normal mitotic spindle

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Genotypes:

FYPO:0006917 - normal onset of mitotic metaphase/anaphase transition

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Genotypes:

FYPO:0004082 - normal protein phosphorylation during mitosis

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Genotypes:

FYPO:0001124 - normal vegetative cell size

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Genotypes:

FYPO:0006928 - nuclear membrane blebbing

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0006930 - sensitive to butylated hydroxyanisole

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Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

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Genotypes:

FYPO:0003840 - sensitive to carbendazim

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0007570 - septation initiation network signaling from both mitotic spindle pole bodies

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPFAM
cd08217STKc_Nek2CDD
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE_PATTERNS
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE_PROFILES
SM00220serkin_6Prot_kinase_domSMART
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
G3DSA:1.10.510.10Transferase(Phosphotransferase) domain 1GENE3D
G3DSA:3.30.200.20Phosphorylase Kinase; domain 1GENE3D
PTHR44899CAMK FAMILY PROTEIN KINASENEK_Ser/Thr_kinase_NIMAPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.
Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.
Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813
PMID:11927555 - The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.
Krien MJ et al. EMBO J 2002 Apr 02;21(7):1713-22
PMID:12546793 - Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.
Krapp A et al. Curr Biol 2003 Jan 21;13(2):168-72
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25501814 - The septation initiation network controls the assembly of nodes containing Cdr2p for cytokinesis in fission yeast.
Pu KM et al. J Cell Sci 2015 Feb 01;128(3):441-6
PMID:12065422 - Schizosaccharomyces pombe NIMA-related kinase, Fin1, regulates spindle formation and an affinity of Polo for the SPB.
Grallert A et al. EMBO J 2002 Jun 17;21(12):3096-107
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:22684255 - The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.
Grallert A et al. Nat Cell Biol 2012 Jun 10;14(7):738-45
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:11707530 - Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombe.
Huang HK et al. J Cell Sci 2001 Oct;114(Pt 20):3779-88
PMID:9490640 - A NIMA homologue promotes chromatin condensation in fission yeast.
Krien MJ et al. J Cell Sci 1998 Apr;111 ( Pt 7):967-76
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:22375062 - Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.
Buttrick GJ et al. J Cell Sci 2012 Apr 01;125(Pt 7):1645-51
PMID:10473635 - Rad18 is required for DNA repair and checkpoint responses in fission yeast.
Verkade HM et al. Mol Biol Cell 1999 Sep;10(9):2905-18
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:12411492 - Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle.
Anderson M et al. EMBO J 2002 Nov 01;21(21):5745-55
PMID:15509866 - Fkh2p and Sep1p regulate mitotic gene transcription in fission yeast.
Buck V et al. J Cell Sci 2004 Nov 01;117(Pt 23):5623-32
PMID:23333317 - Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.
Grallert A et al. Curr Biol 2013 Feb 04;23(3):213-22
PMID:15132994 - Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity.
Grallert A et al. Genes Dev 2004 May 01;18(9):1007-21
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:28774892 - Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment.
Chan KY et al. J Cell Biol 2017 Sep 04;216(9):2795-2812
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18057023 - Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors.
Papadopoulou K et al. J Cell Sci 2008 Jan 01;121(Pt 1):38-47
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.
Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14