protein coding gene - cut20 (SPAC19G12.01c) - anaphase-promoting complex platform subcomplex scaffold WD repeat subunit Apc4/Cut20

Gene summary

Standard name

cut20

Systematic ID

SPAC19G12.01c

Product

anaphase-promoting complex platform subcomplex scaffold WD repeat subunit Apc4/Cut20

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

lid1, apc4, SPAPJ698.04c

UniProt ID

O42839

ORFeome ID

46/46H03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4041809..4044624 reverse strand

Annotation

Protein features

Orthologs

• ANAPC4 (HGNC:19990) Homo sapiens
• cut20 (SJAG_02186) Schizosaccharomyces japonicus
• APC4 (YDR118W) Saccharomyces cerevisiae

References / Literature

PMID:16149916 - Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.

Jossé L et al. Biochem J 2006 Jan 01;393(Pt 1):303-9

PMID:18082611 - Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.

Ohi MD et al. Mol Cell 2007 Dec 14;28(5):871-85

PMID:10526233 - Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses.

Yamashita YM et al. Genes Cells 1999 Aug;4(8):445-63

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15060174 - Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27.

Schwickart M et al. Mol Cell Biol 2004 Apr;24(8):3562-76

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24948786 - Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe.

Elmore ZC et al. G3 (Bethesda) 2014 Jun 19;4(8):1529-38

PMID:18556659 - The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).

Sczaniecka M et al. J Biol Chem 2008 Aug 22;283(34):23039-47

PMID:12653962 - A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.

Matsumura T et al. Genes Cells 2003 Apr;8(4):341-55

PMID:28366743 - Different Functionality of Cdc20 Binding Sites within the Mitotic Checkpoint Complex.

Sewart K et al. Curr Biol 2017 Apr 24;27(8):1213-1220

PMID:19592249 - A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism.

Vanoosthuyse V et al. Curr Biol 2009 Jul 28;19(14):1176-81

PMID:28366744 - Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest.

May KM et al. Curr Biol 2017 Apr 24;27(8):1221-1228

PMID:36108046 - Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism.

Bai S et al. PLoS Genet 2022 Sep;18(9):e1010397

PMID:21664573 - Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.

Meadows JC et al. Dev Cell 2011 Jun 14;20(6):739-50

PMID:16950791 - Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function.

Yoon HJ et al. J Biol Chem 2006 Oct 27;281(43):32284-93

PMID:12668659 - An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation.

Tasto JJ et al. J Cell Biol 2003 Mar 31;160(7):1093-103

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:10082519 - The schizosaccharomyces pombe dim1(+) gene interacts with the anaphase-promoting complex or cyclosome (APC/C) component lid1(+) and is required for APC/C function.

Berry LD et al. Mol Cell Biol 1999 Apr;19(4):2535-46

PMID:22281223 - Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.

Zich J et al. Curr Biol 2012 Feb 21;22(4):296-301

PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.

Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94

PMID:12477395 - Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes.

Yoon HJ et al. Curr Biol 2002 Dec 10;12(23):2048-54

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26882497 - Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.

Zich J et al. PLoS Genet 2016 Feb;12(2):e1005834

PMID:24583014 - Slow checkpoint activation kinetics as a safety device in anaphase.

Kamenz J et al. Curr Biol 2014 Mar 17;24(6):646-51

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:11533255 - Study of cyclin proteolysis in anaphase-promoting complex (APC) mutant cells reveals the requirement for APC function in the final steps of the fission yeast septation initiation network.

Chang L et al. Mol Cell Biol 2001 Oct;21(19):6681-94

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:10582241 - Control of metaphase-anaphase progression by proteolysis: cyclosome function regulated by the protein kinase A pathway, ubiquitination and localization.

Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 1999 Sep 29;354(1389):1559-69; discussion 1569-70

PMID:11493649 - Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation.

Blanco MA et al. J Cell Sci 2001 Jun;114(Pt 11):2135-43