protein coding gene - hta2 (SPAC19G12.06c) - histone H2A beta

Gene summary

Standard name

hta2

Systematic ID

SPAC19G12.06c

Product

histone H2A beta

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P04910

ORFeome ID

31/31D04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4052446..4053318 reverse strand

Annotation

Protein features

Orthologs

• H2AC12 (HGNC:13671) Homo sapiens
• H2AB3 (HGNC:14455) Homo sapiens
• H2AJ (HGNC:14456) Homo sapiens
• H2AB2 (HGNC:18298) Homo sapiens
• H2AC1 (HGNC:18729) Homo sapiens
• H2AC25 (HGNC:20507) Homo sapiens
• H2AC21 (HGNC:20508) Homo sapiens
• H2AB1 (HGNC:22516) Homo sapiens
• H2AC8 (HGNC:4724) Homo sapiens
• H2AC13 (HGNC:4725) Homo sapiens
• H2AC15 (HGNC:4726) Homo sapiens
• H2AC14 (HGNC:4727) Homo sapiens
• H2AC16 (HGNC:4730) Homo sapiens
• H2AC6 (HGNC:4733) Homo sapiens
• H2AC4 (HGNC:4734) Homo sapiens
• H2AC17 (HGNC:4735) Homo sapiens
• H2AC11 (HGNC:4737) Homo sapiens
• H2AX (HGNC:4739) Homo sapiens
• hta2 (SJAG_01873) Schizosaccharomyces japonicus
• HTA2 (YBL003C) Saccharomyces cerevisiae
• HTA1 (YDR225W) Saccharomyces cerevisiae

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:20661445 - Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.

Rozenzhak S et al. PLoS Genet 2010 Jul 22;6(7):e1001032

PMID:24352239 - Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

Tessarz P et al. Nature 2014 Jan 23;505(7484):564-8

PMID:20094029 - gammaH2A binds Brc1 to maintain genome integrity during S-phase.

Williams JS et al. EMBO J 2010 Mar 17;29(6):1136-48

PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.

Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7

PMID:26368543 - Critical Function of γH2A in S-Phase.

Mejia-Ramirez E et al. PLoS Genet 2015 Sep;11(9):e1005517

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:15226425 - Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM et al. Mol Cell Biol 2004 Jul;24(14):6215-30

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.

Cohen A et al. J Biol Chem 2024 Jul 04;:107531

PMID:24806815 - Mdb1, a fission yeast homolog of human MDC1, modulates DNA damage response and mitotic spindle function.

Wei Y et al. PLoS One 2014;9(5):e97028

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697

PMID:20230746 - Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.

Takayama Y et al. Dev Cell 2010 Mar 16;18(3):385-96

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:34678589 - Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.

Day M et al. DNA Repair (Amst) 2021 Dec;108:103232

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:20679485 - BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.

Sofueva S et al. Mol Cell Biol 2010 Oct;30(19):4732-43

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:19965387 - Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.

Kawashima SA et al. Science 2010 Jan 08;327(5962):172-7

PMID:29769606 - Malonylation of histone H2A at lysine 119 inhibits Bub1-dependent H2A phosphorylation and chromosomal localization of shugoshin proteins.

Ishiguro T et al. Sci Rep 2018 May 16;8(1):7671

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:26804021 - Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

Tashiro S et al. Nat Commun 2016 Jan 25;7:10393

PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Lando D et al. PLoS One 2012;7(1):e29765

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:28784724 - Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.

Reubens MC et al. Mol Cell Biol 2017 Nov 15;37(22)

PMID:30348841 - Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.

Oravcová M et al. Mol Cell Biol 2019 Jan 15;39(2)

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:27890612 - In vitro reconstitution and biochemical analyses of the Schizosaccharomyces pombe nucleosome.

Koyama M et al. Biochem Biophys Res Commun 2017 Jan 22;482(4):896-901

PMID:21098122 - Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks.

Limbo O et al. Mol Cell Biol 2011 Feb;31(3):573-83

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:33670267 - The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.

Dong W et al. Int J Mol Sci 2021 Feb 11;22(4)

PMID:38773107 - The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B.

Sun W et al. Nat Commun 2024 May 21;15(1):4322

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:20929775 - Two histone marks establish the inner centromere and chromosome bi-orientation.

Yamagishi Y et al. Science 2010 Oct 08;330(6001):239-43

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:23656778 - Brc1 links replication stress response and centromere function.

Lee SY et al. Cell Cycle 2013 Jun 01;12(11):1665-71

PMID:16778077 - Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks.

Du LL et al. Genes Dev 2006 Jun 15;20(12):1583-96

PMID:18676809 - Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.

Kilkenny ML et al. Genes Dev 2008 Aug 01;22(15):2034-47

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:22912768 - Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Sugiyama T et al. PLoS One 2012;7(8):e42962

PMID:16540522 - Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.

Nishijima H et al. Mol Biol Cell 2006 Jun;17(6):2524-36

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21633354 - Condensin association with histone H2A shapes mitotic chromosomes.

Tada K et al. Nature 2011 Jun 01;474(7352):477-83

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:20679488 - Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

Sanders SL et al. Mol Cell Biol 2010 Oct;30(19):4722-31

PMID:23080121 - Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.

Limbo O et al. Nucleic Acids Res 2012 Dec;40(22):11435-49

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:16314498 - Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.

Nakamura TM et al. Mol Cell Biol 2005 Dec;25(24):10721-30

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.

Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87