protein coding gene - cpy1 (SPAC19G12.10c) - vacuolar carboxypeptidase Y

Gene summary

Standard name

cpy1

Systematic ID

SPAC19G12.10c

Product

vacuolar carboxypeptidase Y

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

pcy1

UniProt ID

O13849

ORFeome ID

29/29G12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4061377..4064957 reverse strand

Annotation

Protein features

Orthologs

• CTSA (HGNC:9251) Homo sapiens
• cpy1 (SJAG_01868) Schizosaccharomyces japonicus
• ATG42 (YBR139W) Saccharomyces cerevisiae
• PRC1 (YMR297W) Saccharomyces cerevisiae

References / Literature

PMID:25378562 - Vsl1p cooperates with Fsv1p for vacuolar protein transport and homotypic fusion in Schizosaccharomyces pombe.

Hosomi A et al. Microbiology (Reading) 2015 Jan;161(Pt 1):89-98

PMID:17287531 - Valproic acid affects membrane trafficking and cell-wall integrity in fission yeast.

Miyatake M et al. Genetics 2007 Apr;175(4):1695-705

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:32918581 - Golgi localization of glycosyltransferases requires Gpp74p in Schizosaccharomyces pombe.

Ohashi T et al. Appl Microbiol Biotechnol 2020 Oct;104(20):8897-8909

PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.

Idiris A et al. Yeast 2006 Jan 30;23(2):83-99

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:31341193 - Ent3 and GGA adaptors facilitate diverse anterograde and retrograde trafficking events to and from the prevacuolar endosome.

Yanguas F et al. Sci Rep 2019 Jul 24;9(1):10747

PMID:15189449 - Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe.

Koga T et al. Genes Cells 2004 Jun;9(6):561-74

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:9209031 - Vacuolar protein sorting in fission yeast: cloning, biosynthesis, transport, and processing of carboxypeptidase Y from Schizosaccharomyces pombe.

Tabuchi M et al. J Bacteriol 1997 Jul;179(13):4179-89

PMID:22083275 - N-glycans are not required for the efficient degradation of the mutant Saccharomyces cerevisiae CPY* in Schizosaccharomyces pombe.

Mukaiyama H et al. Appl Microbiol Biotechnol 2012 Feb;93(4):1609-18

PMID:14575697 - Identification of a SNARE protein required for vacuolar protein transport in Schizosaccharomyces pombe.

Takegawa K et al. Biochem Biophys Res Commun 2003 Nov 07;311(1):77-82

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:27974503 - Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast.

Hoya M et al. Genetics 2017 Feb;205(2):673-690

PMID:21153812 - Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe.

Mukaiyama H et al. Appl Microbiol Biotechnol 2011 Apr;90(1):203-13

PMID:21899677 - Cdc42 regulates multiple membrane traffic events in fission yeast.

Estravís M et al. Traffic 2011 Dec;12(12):1744-58

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26749213 - The AP-2 complex is required for proper temporal and spatial dynamics of endocytic patches in fission yeast.

de León N et al. Mol Microbiol 2016 May;100(3):409-24

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.

Ramos M et al. iScience 2024 Aug 16;27(8):110477

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:14723709 - Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: the importance of Mn2+ homeostasis.

Maeda T et al. Genes Cells 2004 Jan;9(1):71-82

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:21757403 - Schizosaccharomyces pombe Pep12p is required for vacuolar protein transport and vacuolar homotypic fusion.

Hosomi A et al. J Biosci Bioeng 2011 Oct;112(4):309-14

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:34147496 - Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast.

Sawada N et al. J Biol Chem 2021 Jul;297(1):100891

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:11751918 - The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Taricani L et al. J Biol Chem 2002 Mar 22;277(12):10562-72

PMID:25803873 - Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe.

Núñez A et al. PLoS One 2015;10(3):e0121059