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protein coding gene - dlp1 (SPAC19G12.12) - decaprenyl diphosphate synthase subunit 2 Dlp1

Gene summary

Standard name
dlp1
Systematic ID
SPAC19G12.12
Product
decaprenyl diphosphate synthase subunit 2 Dlp1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
coq1
UniProt ID
O13851
ORFeome ID
12/12A02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4068599..4069929 forward strand

Annotation

Complementation

PBO:0036335 - functionally complemented by human DLP1 AND DPS1

References:

PBO:0123301 - is not functionally complemented by human DLP1

References:

PBO:0123302 - is not functionally complemented by mouse DLP1

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Disease association

MONDO:0013838 - coenzyme Q10 deficiency, primary, 3

References:

GO biological process

GO:0008299 - isoprenoid biosynthetic process

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GO:0006744 - ubiquinone biosynthetic process

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GO cellular component

GO:0032478 - heterotetrameric polyprenyl diphosphate synthase complex

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0097269 - all-trans-decaprenyl-diphosphate synthase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0001712 - coenzyme Q10 absent from cell

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Genotypes:

FYPO:0000246 - growth auxotrophic for antioxidant

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003374 - normal cellular coenzyme Q10 level

References:

Genotypes:

FYPO:0000103 - sensitive to copper

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000020 - protein level unchanged

References:

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003690 - abolished cell population growth on glycerol/ethanol carbon source

References:

Genotypes:

FYPO:0001712 - coenzyme Q10 absent from cell

References:

Genotypes:

FYPO:0001116 - decreased RNA level during cellular response to hydrogen peroxide

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Genotypes:

FYPO:0000246 - growth auxotrophic for antioxidant

References:

Genotypes:

FYPO:0000037 - growth auxotrophic for cysteine

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Genotypes:

FYPO:0003270 - growth auxotrophic for glutathione

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007808 - resistance to valproic acid

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000103 - sensitive to copper

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0009798 - faster evolving duplicate

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
cd00867Trans_IPPSCDD
G3DSA:1.10.600.10Isoprenoid_synthase_dom_sfCATH-Gene3D
SSF48576Isoprenoid_synthase_dom_sfSUPERFAMILY
PTHR12001PANTHER
CoilCOILS

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27837315 - Cloning and characterization of decaprenyl diphosphate synthase from three different fungi.
Moriyama D et al. Appl Microbiol Biotechnol 2017 Feb;101(4):1559-1571
PMID:14519123 - Fission yeast decaprenyl diphosphate synthase consists of Dps1 and the newly characterized Dlp1 protein in a novel heterotetrameric structure.
Saiki R et al. Eur J Biochem 2003 Oct;270(20):4113-21
PMID:18808426 - Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.
Miki R et al. FEBS J 2008 Nov;275(21):5309-24
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16262699 - Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
Saiki R et al. FEBS J 2005 Nov;272(21):5606-22
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37156397 - Identification of novel coenzyme Q 10 biosynthetic proteins Coq11 and Coq12 in Schizosaccharomyces pombe.
Nishida I et al. J Biol Chem 2023 Jun;299(6):104797
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.
Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:33232355 - Benzoic acid inhibits Coenzyme Q biosynthesis in Schizosaccharomyces pombe.
Nishida I et al. PLoS One 2020;15(11):e0242616
PMID:24911838 - Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.
Hayashi K et al. PLoS One 2014;9(6):e99038
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:25647499 - Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.
Moriyama D et al. Biosci Biotechnol Biochem 2015;79(6):1026-33
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36