protein coding gene - poz1 (SPAC19G12.13c) - shelterin complex shelterin bridge subunit Poz1

Gene summary

Standard name

poz1

Systematic ID

SPAC19G12.13c

Product

shelterin complex shelterin bridge subunit Poz1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O13852

ORFeome ID

11/11H09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4068603..4070924 reverse strand

Annotation

Protein features

Orthologs

• TINF2 (HGNC:11824) Homo sapiens
• poz1 (SJAG_01864) Schizosaccharomyces japonicus

References / Literature

PMID:34255844 - The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.

Liu J et al. Nucleic Acids Res 2021 Aug 20;49(14):8110-8119

PMID:26365187 - Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.

Liu J et al. Cell Rep 2015 Sep 29;12(12):2169-80

PMID:24013504 - Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.

Jun HI et al. Genes Dev 2013 Sep 01;27(17):1917-31

PMID:29149597 - Structural Basis for Shelterin Bridge Assembly.

Kim JK et al. Mol Cell 2017 Nov 16;68(4):698-714.e5

PMID:41201383 - Combinatorial Analyses of Pre-mRNA Splicing-Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions.

Takeuchi M et al. Genes Cells 2025 Nov;30(6):e70064

PMID:24711392 - SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.

Miyagawa K et al. Proc Natl Acad Sci U S A 2014 Apr 22;111(16):5950-5

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:25131669 - Telomerase activation after recruitment in fission yeast.

Armstrong CA et al. Curr Biol 2014 Sep 08;24(17):2006-11

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:23133674 - Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe.

Fujita I et al. PLoS One 2012;7(11):e49151

PMID:26063574 - Minishelterins separate telomere length regulation and end protection in fission yeast.

Pan L et al. Genes Dev 2015 Jun 01;29(11):1164-74

PMID:25245948 - Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.

Wang J et al. Nucleic Acids Res 2014 Oct;42(18):11419-32

PMID:26058898 - Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation.

Amelina H et al. BMC Biol 2015 Jun 10;13:37

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:29160296 - Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.

Xue J et al. Cell Res 2017 Dec;27(12):1503-1520

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:29997179 - Shelterin promotes tethering of late replication origins to telomeres for replication-timing control.

Ogawa S et al. EMBO J 2018 Aug 01;37(15)

PMID:31131414 - Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.

Inoue H et al. Nucleic Acids Res 2019 Jul 26;47(13):6871-6884

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:32499408 - The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast.

Sun L et al. J Cell Sci 2020 Jul 07;133(13)

PMID:31289327 - Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins.

Hasegawa Y et al. Sci Rep 2019 Jul 09;9(1):9946

PMID:24240238 - Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Tadeo X et al. Genes Dev 2013 Nov 15;27(22):2489-99

PMID:22354040 - RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts.

Luciano P et al. EMBO J 2012 Apr 18;31(8):2034-46

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26988418 - The proper connection between shelterin components is required for telomeric heterochromatin assembly.

Wang J et al. Genes Dev 2016 Apr 01;30(7):827-39

PMID:24244195 - Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.

Chang YT et al. PLoS Genet 2013 Nov;9(11):e1003936

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:26354422 - Ccq1-Tpz1TPP1 interaction facilitates telomerase and SHREC association with telomeres in fission yeast.

Moser BA et al. Mol Biol Cell 2015 Nov 01;26(21):3857-66

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:18535244 - Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.

Miyoshi T et al. Science 2008 Jun 06;320(5881):1341-4

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:28807855 - Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex.

Scott H et al. J Mol Biol 2017 Sep 15;429(19):2863-2872

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:22959349 - Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation.

Fujita I et al. Curr Biol 2012 Oct 23;22(20):1932-7

PMID:29422503 - LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK et al. Nat Commun 2018 Feb 08;9(1):586

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:25398909 - Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.

Lorenzi LE et al. EMBO J 2015 Jan 02;34(1):115-29

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:26990647 - Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Gadaleta MC et al. PLoS Genet 2016 Mar;12(3):e1005943

PMID:25330395 - Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.

Harland JL et al. PLoS Genet 2014 Oct;10(10):e1004708

PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Garg M et al. EMBO Rep 2014 Aug;15(8):871-7

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:27253066 - Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.

Hu X et al. Elife 2016 Jun 02;5

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7