PomBase home

protein coding gene - erh1 (SPAC19G12.17) - enhancer of rudimentary homolog Erh1

Gene summary

Standard name
erh1
Systematic ID
SPAC19G12.17
Product
enhancer of rudimentary homolog Erh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
new10, iss6
UniProt ID
G2TRN4
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4066258..4066971 reverse strand

Annotation

GO biological process

GO:0033621 - nuclear mRNA surveillance of meiosis-specific transcripts

References:

GO:1902801 - regulation of siRNA-independent facultative heterochromatin formation

References:

GO:0043628 - regulatory ncRNA 3'-end processing

References:

GO cellular component

GO:1905754 - ascospore-type prospore nucleus

References:

GO:0005737 - cytoplasm

References:

GO:1990342 - heterochromatin island

References:

GO:1990251 - nuclear exosome focus

References:

GO:0005654 - nucleoplasm

References:

GO:0005634 - nucleus

References:

GO:0033553 - rDNA heterochromatin

References:

GO molecular function

GO:0140678 - molecular function inhibitor activity

References:

GO:0005515 - protein binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0000016 - curved vegetative cell

References:

Genotypes:

FYPO:0001045 - decreased acid phosphatase activity

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0002243 - increased acid phosphatase activity

References:

Genotypes:

FYPO:0004582 - increased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003267 - normal acid phosphatase activity

References:

Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000112 - sensitive to sorbitol

References:

Genotypes:

FYPO:0002067 - slow cell population growth during recovery from stationary phase

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0007608 - abnormal RNA localization during meiotic cell cycle

References:

Genotypes:

FYPO:0005369 - abolished cell population growth at low temperature

References:

Genotypes:

FYPO:0005208 - abolished protein localization during meiotic cell cycle

References:

Genotypes:

FYPO:0001179 - abolished protein localization during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0002133 - abolished protein-RNA interaction

References:

Genotypes:

FYPO:0005857 - altered antisense RNA level during vegetative growth

References:

Genotypes:

FYPO:0005858 - altered level of translation gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0000016 - curved vegetative cell

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0003216 - decreased chromatin silencing at rDNA

References:

Genotypes:

FYPO:0000876 - decreased histone H3-K9 dimethylation during vegetative growth

References:

Genotypes:

FYPO:0003230 - decreased histone H3-K9 methylation at heterochromatin island during vegetative growth

References:

Genotypes:

FYPO:0000872 - decreased histone H3-K9 methylation during vegetative growth

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0002134 - decreased protein-RNA interaction

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002243 - increased acid phosphatase activity

References:

Genotypes:

FYPO:0004582 - increased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0002960 - increased level of DSR-containing meiotic gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0005868 - increased mitotic recombination at rDNA

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0001890 - increased RNA level

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0005863 - loss of punctate nuclear protein localization

References:

Genotypes:

FYPO:0004909 - loss of punctate nuclear protein localization, with protein distributed in nucleus

References:

Genotypes:

FYPO:0003056 - Mei2 nuclear dot absent from cell

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0003235 - normal histone H3-K9 methylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0005865 - normal histone H3-K9 methylation at silent mating-type cassette during vegetative growth

References:

Genotypes:

FYPO:0005864 - normal histone H3-K9 methylation at subtelomeric heterochromatin during vegetative growth

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0006862 - RNA mislocalized to cytoplasm during vegetative growth

References:

Genotypes:

FYPO:0001188 - sensitive to Calcofluor White

References:

Genotypes:

FYPO:0003840 - sensitive to carbendazim

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0000112 - sensitive to sorbitol

References:

Genotypes:

FYPO:0002067 - slow cell population growth during recovery from stationary phase

References:

Genotypes:

Subunit composition

PBO:0015212 - homomeric(2)

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0000070 - gene structure updated

References:

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF01133ERERHPfam
G3DSA:3.30.2260.10EHR_sfCATH-Gene3D
SSF143875EHR_sfSUPERFAMILY
PTHR12373ERHPANTHER

Orthologs

References / Literature

PMID:30651569 - A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing.
Xie G et al. Nat Commun 2019 Jan 16;10(1):251
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:32546512 - Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination.
Schwer B et al. RNA 2020 Oct;26(10):1334-1344
PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819
PMID:42420319 - Spliceosomal proteins direct RNA methylation to modulate gene expression and silence retrotransposons.
Vijayakumari D et al. Nat Commun 2026 Jul 08;
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.
Simonetti F et al. Elife 2017 Aug 25;6
PMID:23145069 - Identification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosaccharomyces pombe.
Krzyzanowski MK et al. PLoS One 2012;7(11):e49059
PMID:23980030 - A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.
Yamashita A et al. Nucleic Acids Res 2013 Nov;41(21):9680-7
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:29424342 - YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.
Shichino Y et al. Elife 2018 Feb 09;7
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70
PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.
Schwer B et al. mBio 2024 Jun 20;:e0125224
PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.
Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898
PMID:35512546 - Structural insights reveal the specific recognition of meiRNA by the Mei2 protein.
Shen S et al. J Mol Cell Biol 2022 Sep 19;14(5)
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:26942678 - Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.
Sugiyama T et al. Mol Cell 2016 Mar 03;61(5):747-759
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:31974447 - Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression.
Hazra D et al. Sci Rep 2020 Jan 23;10(1):1034
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83