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protein coding gene - cox6 (SPAC1B2.04) - cytochrome c oxidase subunit VI

Gene summary

Standard name
cox6
Systematic ID
SPAC1B2.04
Product
cytochrome c oxidase subunit VI
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTF6
ORFeome ID
10/10G12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2814293..2815495 forward strand

Annotation

Disease association

MONDO:0033655 - mitochondrial complex IV deficiency, nuclear type 20

References:

GO biological process

GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0005739 - mitochondrion

References:

GO:0045277 - respiratory chain complex IV

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GO molecular function

GO:0004129 - cytochrome-c oxidase activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0007368 - increased energy charge

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003730 - abolished cell population growth on galactose carbon source

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Genotypes:

FYPO:0006141 - abolished cell population growth on gluconate carbon source

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Genotypes:

FYPO:0001934 - abolished cell population growth on glycerol carbon source

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Genotypes:

FYPO:0001563 - decreased cellular glutamate level

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0002009 - decreased oxygen consumption during vegetative growth

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0007618 - delayed onset of protein export from nucleus

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Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

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Genotypes:

FYPO:0007612 - increased transcription from STREP promoter

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0004325 - sensitive to 5-fluorouracil

References:

Genotypes:

FYPO:0007921 - sensitive to benzamidine

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Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000102 - sensitive to cisplatin

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Genotypes:

FYPO:0003559 - sensitive to doxorubicin

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02284COX5ACyt_c_oxidase_su5A/6PFAM
cd00923Cyt_c_Oxidase_VaCyt_c_oxidase_su5A/6CDD
G3DSA:1.25.40.40:FF:000001FUNFAM
SSF48479Cytochrome c oxidase subunit ECyt_c_oxidase_su5A/6_sfSUPERFAMILY
G3DSA:1.25.40.40Cytochrome c oxidase, subunit Va/VICyt_c_oxidase_su5A/6_sfGENE3D
PTHR14200CYTOCHROME C OXIDASE POLYPEPTIDECyt_c_oxidase_su5A/6PANTHER

Orthologs

References / Literature

PMID:37939086 - Structure and function of the S. pombe III-IV-cyt c supercomplex.
Moe A et al. Proc Natl Acad Sci U S A 2023 Nov 14;120(46):e2307697120
PMID:21965289 - Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.
Buttrick GJ et al. Mol Biol Cell 2011 Dec;22(23):4486-502
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.
Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480
PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.
Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
PMID:37445861 - Resistance to Chemotherapeutic 5-Fluorouracil Conferred by Modulation of Heterochromatic Integrity through Ino80 Function in Fission Yeast.
Lim KK et al. Int J Mol Sci 2023 Jun 26;24(13)
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PMID:36797353 - Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor.
Moe A et al. Commun Chem 2023 Feb 16;6(1):32
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37164017 - Optimization of energy production and central carbon metabolism in a non-respiring eukaryote.
Alam S et al. Curr Biol 2023 Jun 05;33(11):2175-2186.e5
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:26791325 - Predicting chemotherapeutic drug combinations through gene network profiling.
Nguyen TT et al. Sci Rep 2016 Jan 21;6:18658
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.
Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842
PMID:26891792 - Calcium modulation of doxorubicin cytotoxicity in yeast and human cells.
Nguyen TT et al. Genes Cells 2016 Mar;21(3):226-40
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23365689 - Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.
Tay Z et al. PLoS One 2013;8(1):e55041
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees