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protein coding gene - ypt4 (SPAC1B3.11c) - GTPase Ypt4

Gene summary

Standard name
ypt4
Systematic ID
SPAC1B3.11c
Product
GTPase Ypt4
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13876
ORFeome ID
43/43B04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4948541..4950112 reverse strand

Annotation

GO biological process

GO:0006887 - exocytosis

References:

GO:0023052 - signaling

References:

GO:0007033 - vacuole organization

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0016020 - membrane

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005525 - GTP binding

References:

GO:0003924 - GTPase activity

References:

Modification

MOD:00441 - geranylgeranylated residue

References:

Multi-locus phenotype

FYPO:0000123 - large vacuoles during vegetative growth

References:

Genotypes:

FYPO:0004715 - large vacuoles present in decreased numbers during salt stress

References:

Genotypes:

FYPO:0006266 - normal vacuole size during vegetative growth

References:

Genotypes:

Protein features

PBO:0111858 - Ypt subfamily

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0000123 - large vacuoles during vegetative growth

References:

Genotypes:

FYPO:0006265 - large vacuoles present following cellular hypotonic response

References:

Genotypes:

FYPO:0002795 - large vacuoles present in decreased numbers during vegetative growth

References:

Genotypes:

FYPO:0000426 - normal endocytosis

References:

Genotypes:

FYPO:0001945 - normal protein secretion

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0001987 - sensitive to high pH

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00071RasSmall_GTPasePFAM
cd00154RabCDD
PS51420RHOPROSITE_PROFILES
PS51419RABPROSITE_PROFILES
PS51421RASSmall_GTPasePROSITE_PROFILES
SM00174rho_sub_3Small_GTPaseSMART
SM00173ras_sub_4SMART
SM00176ran_sub_2SMART
SM00175rab_sub_5SMART
PR00449RASTRNSFRMNGPRINTS
G3DSA:3.40.50.300:FF:001072FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR47979DRAB11-RELATEDRab_GTPases_membrane_trafficPANTHER
TIGR00231small_GTPSmall_GTP-bdNCBIFAM

Orthologs

References / Literature

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Liu NN et al. Cell Res 2010 Aug;20(8):963-5
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:28944093 - Ypt4 and lvs1 regulate vacuolar size and function in Schizosaccharomyces pombe .
Rains A et al. Cell Logist 2017;7(3):e1335270
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000002 - Comments
PMID:9443913 - Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases.
Bone N et al. Curr Biol 1998 Jan 29;8(3):135-44
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000051 - S. pombe keyword mapping