PomBase home

protein coding gene - vma3 (SPAC1B3.14) - V-type ATPase V0 subunit c (proteolipid subunit)

Gene summary

Standard name
vma3
Systematic ID
SPAC1B3.14
Product
V-type ATPase V0 subunit c (proteolipid subunit)
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P50515
ORFeome ID
10/10C12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4954579..4955675 forward strand

Annotation

Disease association

MONDO:0958196 - epilepsy, early-onset, 3, with or without developmental delay

References:

MONDO:0700092 - neurodevelopmental disorder

References:

GO biological process

GO:1902600 - proton transmembrane transport

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0000329 - fungal-type vacuole membrane

References:

GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0046961 - proton-transporting ATPase activity, rotational mechanism

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002794 - abnormal vacuole

References:

Genotypes:

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

References:

Genotypes:

FYPO:0002653 - decreased vacuolar import

References:

Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0000757 - sensitive to nigericin

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00137ATP-synt_CATPase_proteolipid_c-like_domPFAM
cd18176ATP-synt_Vo_c_ATP6C_rpt2CDD
cd18175ATP-synt_Vo_c_ATP6C_rpt1CDD
PR00122VACATPASEATPase_proteolipid_csuPRINTS
G3DSA:1.20.120.610:FF:000001FUNFAM
SSF81333F1F0 ATP synthase subunit CF/V-ATP_Csub_sfSUPERFAMILY
G3DSA:1.20.120.610F/V-ATP_Csub_sfGENE3D
PTHR10263V-TYPE PROTON ATPASE PROTEOLIPID SUBUNITPANTHER
TIGR01100V_ATP_synt_CATPase_proteolipid_su_C_eukNCBIFAM

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:16849797 - A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant.
Iwaki T et al. Microbiology (Reading) 2006 Aug;152(Pt 8):2309-2321
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23521895 - Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension.
Stephan J et al. Aging Cell 2013 Aug;12(4):574-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:14735354 - Characterization of Schizosaccharomyces pombe mutants defective in vacuolar acidification and protein sorting.
Iwaki T et al. Mol Genet Genomics 2004 Mar;271(2):197-207
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:36074901 - ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder often associated with epilepsy.
Mattison KA et al. Brain 2023 Apr 19;146(4):1357-1372
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6