protein coding gene - sck1 (SPAC1B9.02c) - serine/threonine protein kinase S6K family Sck1

Gene summary

Standard name

sck1

Systematic ID

SPAC1B9.02c

Product

serine/threonine protein kinase S6K family Sck1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P50530

ORFeome ID

51/51E10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2402016..2404703 reverse strand

Annotation

Protein features

Orthologs

• SGK1 (HGNC:10810) Homo sapiens
• SGK3 (HGNC:10812) Homo sapiens
• SGK2 (HGNC:13900) Homo sapiens
• AKT1 (HGNC:391) Homo sapiens
• AKT2 (HGNC:392) Homo sapiens
• sck1 (SJAG_02426) Schizosaccharomyces japonicus
• SCH9 (YHR205W) Saccharomyces cerevisiae

References / Literature

PMID:11180454 - The cyclic AMP/PKA signal pathway is required for initiation of spore germination in Schizosaccharomyces pombe.

Hatanaka M et al. Yeast 2001 Feb;18(3):207-17

PMID:12615979 - Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase.

Reynolds N et al. J Cell Sci 2003 Apr 01;116(Pt 7):1377-87

GO_REF:0000002 - Comments

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:23074192 - Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling.

Becker M et al. Nucleic Acids Res 2012 Dec;40(22):11648-58

PMID:16822282 - Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2.

Roux AE et al. Aging Cell 2006 Aug;5(4):345-57

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model

PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:28264193 - Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.

Tatebe H et al. Elife 2017 Mar 07;6

PMID:34499159 - Fission yeast TOR complex 1 phosphorylates Psk1 through an evolutionarily conserved interaction mediated by the TOS motif.

Morozumi Y et al. J Cell Sci 2021 Oct 01;134(19)

PMID:19409973 - A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity.

Chen BR et al. Exp Gerontol 2009 Aug;44(8):493-502

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:22976295 - Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.

Nakashima A et al. J Cell Sci 2012 Dec 01;125(Pt 23):5840-9

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:24297439 - Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.

Mudge DK et al. Eukaryot Cell 2014 Feb;13(2):202-8

PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28476936 - Genome-wide screen for cell growth regulators in fission yeast.

Weston L et al. J Cell Sci 2017 Jun 15;130(12):2049-2055

PMID:18057023 - Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors.

Papadopoulou K et al. J Cell Sci 2008 Jan 01;121(Pt 1):38-47

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:9560431 - S. pombe sck2+, a second homologue of S. cerevisiae SCH9 in fission yeast, encodes a putative protein kinase closely related to PKA in function.

Fujita M et al. Curr Genet 1998 Apr;33(4):248-54

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71

PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.

Chia KH et al. Elife 2017 Dec 04;6

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.

Morozumi Y et al. iScience 2024 Jan 19;27(1):108777

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:26152587 - TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.

Laor D et al. mBio 2015 Jul 07;6(4):e00959

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:11004189 - Characterization of tpp1(+) as encoding a main trehalose-6P phosphatase in the fission yeast Schizosaccharomyces pombe.

Franco A et al. J Bacteriol 2000 Oct;182(20):5880-4

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:7498728 - sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.

Jin M et al. Genetics 1995 Jun;140(2):457-67

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:9245826 - Protein kinase Sck1 is involved in trehalase activation by glucose and nitrogen source in the fission yeast Schizosaccharomyces pombe.

Soto T et al. Microbiology (Reading) 1997 Jul;143 ( Pt 7):2457-2463

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704