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protein coding gene - pis1 (SPAC1D4.08) - phosphatidylinositol synthase (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) Pis1

Gene summary

Standard name
pis1
Systematic ID
SPAC1D4.08
Product
phosphatidylinositol synthase (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) Pis1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10153
ORFeome ID
15/15F08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 650473..652224 forward strand

Annotation

GO biological process

GO:0006661 - phosphatidylinositol biosynthetic process

References:

GO cellular component

GO:0005789 - endoplasmic reticulum membrane

References:

GO:0000139 - Golgi membrane

References:

GO:0005741 - mitochondrial outer membrane

References:

GO molecular function

GO:0003881 - CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF01066CDP-OH_P_transfCDP-OH_P_transPFAM
PS00379CDP_ALCOHOL_P_TRANSFCDP_ALCOHOL_P_TRANSF_CSPROSITE_PATTERNS
G3DSA:1.20.120.1760:FF:000011FUNFAM
G3DSA:1.20.120.1760CDP-OH_PTrfase_TM_domGENE3D
PTHR15362PHOSPHATIDYLINOSITOL SYNTHASEPANTHER
PIRSF000848CDP_diag_ino_3_PCDP_diag_ino_3_P_eukPIRSF

Orthologs

References / Literature

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:1324908 - Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe.
Gaynor PM et al. J Bacteriol 1992 Sep;174(17):5711-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24929437 - The translational landscape of fission-yeast meiosis and sporulation.
Duncan CD et al. Nat Struct Mol Biol 2014 Jul;21(7):641-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663